Caffeine Improves Barrier Function in Male Skin

    J. M. Brandner, Martin J. Behne, B. Huesing, Ingrid Moll
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    Studysummary This study found that applying caffeine significantly improved the skin barrier function of male volunteers by reducing transepidermal water loss compared to female volunteers.
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    The study investigated the effects of caffeine on skin barrier function, particularly in male skin, which is typically disadvantaged due to the influence of androgens like testosterone. Conducted as a double-blind placebo-controlled study, 0.5% caffeine in a hydroxyethylcellulose gel was applied to the forearms of male and female volunteers over 7 days. The results showed that caffeine significantly reduced transepidermal water loss (TEWL) in male skin compared to female skin, suggesting that caffeine can improve barrier function in male skin by counteracting testosterone-induced effects.
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