Effects of a Complex Mixture Prepared from Agrimonia, Houttuynia, Licorice, Peony, and Phellodendron on Human Skin Cells
December 2020
in “
Scientific Reports
”
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Studysummary This study found that a mixture of plant extracts significantly improved skin barrier function, reduced inflammation, and exhibited anti-aging effects in human skin cells. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated the effects of a plant extract mixture (AHLPP) from agrimonia, houttuynia, licorice, peony, and phellodendron on human skin cells, focusing on skin barrier function, inflammation, and aging. The AHLPP mixture was found to downregulate pro-inflammatory cytokines like IL 1-β and IL 7, increase procollagen peptide synthesis, and upregulate mRNA of barrier proteins such as filaggrin and desmoplakin. It also demonstrated anti-aging effects by enhancing telomerase activity and altering gene expression related to aging, such as TERT and CDKN1B. The mixture, even when sterilized with γ-irradiation, retained its beneficial properties, suggesting its potential use in skin protection by modulating significant skin-related genes.
