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research Disruption of P2RY5, an orphan G protein–coupled receptor, underlies autosomal recessive woolly hair

210 citations , February 2008 in “Nature genetics”

This study found mutations in the P2RY5 gene that are linked to autosomal recessive woolly hair in Pakistani families, implicating it in hair texture determination.

research A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels

5 citations , January 2018

This study optimized a screening assay to identify molecules that inhibit or enhance TRPM5 ion channel activity, which may have implications for treating dysfunctions linked to cardiac arrhythmias and diabetes.

research Reviewer #3 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis

May 2023

This study found that somatosensory axons innervating Merkel cells in adult mouse skin exhibit significant plasticity, influenced by epithelial and neural factors, indicating a complex interaction in maintaining homeostasis.

research Sustained release of inhibitor from bionic scaffolds for wound healing and functional regeneration

8 citations , January 2020 in “Biomaterials Science”

In this study, small molecule-loaded silk fibroin nanofiber scaffolds with chitosan achieved sustained release of GSK-3 inhibitor SB216763, leading to enhanced wound healing and hair follicle neogenesis in skin regeneration efforts.

research Expression of truncated latent TGF-β-binding protein modulates TGF-β signaling

40 citations , May 2005 in “Journal of Cell Science”

In this study, transgenic mice expressing a truncated form of latent transforming growth factor-β-binding protein exhibited altered hair cycles due to increased active transforming growth factor-β, impacting keratinocyte proliferation and hair cycle phases.

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Community Join

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community My experience with fin, dut, ru, and minoxidil. 25M (around 2 years of fin, 1 year ru, 4 years minoxidil, 1.5 years dut)

38 upvotes 3 months ago

A 25-year-old male experienced hair improvement using finasteride, minoxidil, and RU58841, but saw hair thinning after switching to dutasteride and stopping RU. He plans to continue dutasteride for six months while considering adding RU back due to its positive effects on scalp itch and inflammation.

community [18M] 3 months progress. Went from looking like a 35yo divorced dad to having a better hairline than at 14.

in Progress Pictures 151 upvotes 7 months ago

An 18-year-old shared his 3-month hair regrowth progress using Kirkland 5% topical minoxidil and a dermaroller, achieving a better hairline without finasteride. He plans to switch from liquid to foam minoxidil for easier styling and is cautious about starting finasteride due to potential hormonal effects.

community Please help! Continuously thinning while on Fin 1 mg

in Finasteride/Dutasteride 7 upvotes 7 months ago

The user is experiencing continued hair thinning despite taking Finasteride 1 mg daily for over a year and is hesitant to try Minoxidil due to potential side effects and inconsistency. Suggestions include trying topical Minoxidil once a day, considering oral Minoxidil, and possibly getting a skin biopsy to determine the type of hair loss.

community CRAZY HIGH? 1% Fin 0.3% GHK-CU topical perscription

2 upvotes 7 months ago

The conversation discusses concerns about using a high concentration of 1% topical finasteride for hairline balding, with some users suggesting starting with a lower dose. It also mentions the use of GHK-CU peptide and the importance of considering the formulation to avoid excessive absorption.

community 14 month progress update - 4 in 1 topical solution (sorry for the low quality before)

59 upvotes 1 month ago

The user shared a 14-month progress update using a 4-in-1 topical solution containing 0.3% finasteride, 7% minoxidil, 2.2% ketoconazole, and 0.2% biotin, applied nightly. They reported good results without microneedling and prefer the topical form over oral medication.

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Learn

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learn Hair Transplant

What happens after a hair transplant? Expect mild swelling and redness, with new hair growth starting in 3 to 6 months.
How should I sleep after a hair transplant? Sleep with your head elevated and on your back for the first 3-15 nights.

learn Dutasteride

Dutasteride side effects: what the label and studies actually report The Avodart label reports impotence in 4.7% and decreased libido in 3.0% of men in the first six months (1.7% and 1.4% on placebo), with new reports falling after month six; those figures come from BPH trials in older men, and the hair-loss trials in younger men run only six months. The label and studies also flag a PSA drop of about half, a small rise in high-grade prostate cancer in one trial, an observational link to depression, and sexual effects that the label says may persist after stopping.

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Clinics

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SMP
No. 14 Hair ClinicSouthampton, England · GB

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