Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration

June 2016 in “ PloS one ”

Sang Goo Lee, Mingqian Huang, Nikolaus Obholzer, Shan Sun, Wenyan Li, Marco Petrillo, Pu Dai, Yi Zhou, Douglas A. Cotanche, Sean G. Megason, Huawei Li, Zhengyi Chen

Myc Fgf neuromast hair cells regeneration signaling pathways proliferation differentiation hair cell progenitors

TLDR Zebrafish need MYC and FGF to regenerate inner ear hair cells.

The study concluded that Myc and Fgf signaling pathways were essential for the regeneration of neuromast hair cells in zebrafish. Blocking these pathways significantly reduced hair cell regeneration, indicating their critical roles in the proliferation and differentiation of hair cell progenitors. The findings provided insights into the molecular mechanisms of hair cell regeneration, suggesting potential therapeutic targets for treating hearing loss and balance disorders in humans.

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