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Research

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research 1420 Ashwagandha-derived exosome-like nanoparticles promote human hair growth ex vivo

April 2023 in “Journal of Investigative Dermatology”

This study examined Ashwagandha-derived exosome-like nanoparticles and found that they increased hair growth markers and hair shaft production in human hair follicles ex vivo, suggesting potential for plant-derived exosome therapies in hair loss treatments.

Epidermal Stem Cells Are Defined by Global Histone Modifications Altered by Myc-Induced Differentiation

research Epidermal Stem Cells Are Defined by Global Histone Modifications that Are Altered by Myc-Induced Differentiation

98 citations , August 2007 in “PLoS ONE”

This study found that Myc activation in epidermal stem cells leads to chromatin modifications that promote stem cell exit and differentiation, which can be influenced by HDAC inhibitors like trichostatin A.

Ashwagandha Seed Plant Exosome-Like Nanovesicles Promote In Vitro Cellular Regeneration of Human Dermal Hair Follicle, Endothelial and Fibroblast Cells

research LB1024 Ashwagandha (Withania somnifera) seed plant exosome-like nanovesicles promote in vitro cellular regeneration of human dermal hair follicle, endothelial and fibroblast cells

1 citations , July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that Ashwagandha-derived nanovesicles increased cell proliferation, angiogenesis, and growth factor expression in vitro, suggesting they may have potential as a plant-based alternative or complement to current therapies for hair and skin conditions.

research Targeting ferroptosis in photoaging: mechanisms and therapeutic potential of adipose-derived stem cell exosomes

March 2026 in “Plastic and Aesthetic Research”

This review highlights that exosomes from adipose-derived stem cells, particularly those enriched with circ-Ash1l, can inhibit ferroptosis and reduce UVB-induced skin aging by delivering GPX4-promoting signals to damaged cells, thus offering a potential regenerative therapy for photoaged skin.

research Pigmentation Effect of Rice Bran Extracted Minerals Comprising Soluble Silicic Acids

11 citations , January 2016 in “Evidence-based Complementary and Alternative Medicine”

This study found that rice bran ash extract and orthosilicic acid both increased melanin synthesis and related protein expression in melanocytes, suggesting potential therapeutic use for melanin deficiency.

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community This shedding phase is brutal man…

590 upvotes 1 year ago

The user is experiencing a difficult shedding phase after starting a hair loss treatment with oral finasteride, topical minoxidil, and microneedling. Despite the shedding, they remain hopeful for regrowth and plan to continue the treatment, encouraged by others' positive results.

community Taking ashwagandha and finasteride

8 upvotes 2 months ago

Taking ashwagandha with finasteride is generally not a concern as finasteride blocks DHT conversion, and ashwagandha's effect on testosterone is minimal. Ashwagandha can be beneficial for stress and sleep, but users should monitor for any long-term side effects.

community Anyone tried combining Finasteride and Ashwagandha?

4 upvotes 5 years ago

The conversation discusses using finasteride and ashwagandha for hair loss, with some users noting potential benefits and drawbacks. Minoxidil, peppermint oil, and creatine are also mentioned, with mixed opinions on their effectiveness.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community Finasteride + Ashwagandha. Inputs ?

7 upvotes 3 years ago

Finasteride and Ashwagandha are discussed as potential treatments for hair loss, with mixed opinions on Ashwagandha's effectiveness and safety. Some users report no benefits from Ashwagandha, while others caution against its use due to potential liver issues.

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