Lack of Effect of a Spironolactone-Containing Cream on Hair Growth in Hirsute Women

January 1987 in “ Dermatology ”

Fulgencio Gómez, Albert‐Adrien Ramelet, B Rüedi, M.F. Muhlemann

spironolactone androgen-dependent hirsutism contact dermatitis antiandrogenic effects

TLDR The spironolactone cream did not reduce hair growth in women with hirsutism.

A placebo-controlled study involving 12 women with moderate androgen-dependent hirsutism found that a cream containing 5% spironolactone had no effect on hair growth over a 3-month period. Despite previous reports of success with similar treatments, this study observed no improvement in hirsutism or hair growth. Additionally, one patient developed contact dermatitis from the spironolactone cream. The study raised questions about the formulation's effectiveness and the drug's ability to reach the target site, suggesting that the antiandrogenic effects of spironolactone in hirsutism might be due to systemic rather than local action.

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community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

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community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

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community Finally seeing a modest gain after over 1 year on fin and 3 months on minox. I actually have my part returning!

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community where does the renewed spironolactone hype come from?

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community It’s over. NOTHING has worked.

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community I am a dermatologist with a clinical interest in alopecia. AMA

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