Spironolactone Reduces Hair Growth in Idiopathic Hirsutism

    November 1982 in “ Inpharma ”
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    TLDR Spironolactone reduces hair growth in women with unexplained excessive hairiness.
    In a study from 1982, 21 women with idiopathic hirsutism were treated with spironolactone (25mg twice daily) for an average of 221 days. The treatment resulted in a reduction of hair growth in 57% of the participants, as evidenced by a decreased need for hair removal. Additionally, 52% of the women experienced softer hair, and 38% noticed their hair became lighter in color. Overall, 71% of the patients saw a beneficial effect from the treatment. Laboratory tests showed that steroid levels in serum and urine remained normal, and there was no change in hair density or length. Side effects were reported by 52% of the patients, including breast changes in 48% and menstrual irregularities in 19%. Despite the side effects, patients were generally satisfied with the treatment outcomes. The study suggested that spironolactone could be a preferred option for managing hirsutism when used alongside mechanical and chemical hair removal methods.
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