Preparation and Clinical Assessment of Spironolactone-Containing Cream on Hair Growth in Hirsute Women

March 2001

Nadia Saadat, Peyman Salehi, Azadeh Emami, A.R. Mortazavi

spironolactone hirsutism hair growth cream formulation aqueous cream base

TLDR The 2% spironolactone cream did not reduce hair growth in women with facial hirsutism.

The study aimed to prepare and evaluate the clinical effects of a 2% spironolactone-containing cream on hair growth in 12 women aged 17-50 years with mild to moderate facial hirsutism. Various cream formulations were tested for their physico-chemical properties, and the aqueous cream base was found to be the most stable. However, after applying the cream twice daily for 3 months, the results showed no significant effect on hair growth compared to the untreated side of the face. The study concluded that the 2% spironolactone cream was ineffective in reducing hair growth, suggesting that other formulations or dosages should be explored in future research.

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community No, Finasteride as a treatment for MPB was not an "accident"

in Research/Science 105 upvotes 3 years ago

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

in Progress Pictures 224 upvotes 8 months ago

A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

in Female 53 upvotes 1 year ago

A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

community Any balding females? I need advice with coping :(

16 upvotes 8 years ago

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community Finally seeing a modest gain after over 1 year on fin and 3 months on minox. I actually have my part returning!

in Progress Pictures 808 upvotes 3 years ago

User sees modest hair gain after 1 year on finasteride and 3 months on minoxidil. Others offer support and share experiences with hair loss treatments.

community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

in Update 35 upvotes 5 years ago

The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

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