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    Glossary Topical Spironolactone

    Topical spironolactone is a medication used in the treatment of androgenetic alopecia, particularly in women. It functions as an anti-androgen, inhibiting the effects of male hormones that can contribute to hair loss. Its relevance lies in its ability to reduce hair thinning and promote regrowth by blocking androgen receptors in hair follicles. Key distinguishing characteristics include its application as a topical solution or foam, which allows for localized treatment with potentially fewer systemic side effects compared to oral forms of spironolactone.

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    1. Estradiol Estrogen hormone, prescribed in tablet, patch and gel forms
    2. Cyproterone a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
    3. Fluridil Topical anti-androgen sold as a cosmetic lotion
    4. Clascoterone Topical androgen-receptor blocker, approved as an acne cream
    5. Pyrilutamide Experimental topical anti-androgen, also known as KX-826