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    Glossary Topical Spironolactone

    Topical spironolactone is a medication used in the treatment of androgenetic alopecia, particularly in women. It functions as an anti-androgen, inhibiting the effects of male hormones that can contribute to hair loss. Its relevance lies in its ability to reduce hair thinning and promote regrowth by blocking androgen receptors in hair follicles. Key distinguishing characteristics include its application as a topical solution or foam, which allows for localized treatment with potentially fewer systemic side effects compared to oral forms of spironolactone.

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    1. S125 Topical treatment of androgenetic alopecia with spironolactone Journal of The European Academy of Dermatology and Venereology · 1997 · 2 citations
    2. Topical Spironolactone in the Treatment of Ocular Graft-Versus-Host Disease Curēus · 2023 · 2 citations
    3. Dermoscopic evaluation of the efficacy of combination of topical spironolactone 5% and minoxidil 5% solutions in the treatment of androgenetic alopecia: A cross sectional‐comparative study Journal of Cosmetic Dermatology · 2022 · 1 citations
    4. Topical Spironolactone in the Treatment of Evaporative Dry Eye Disease Cureus · 2023 · 1 citations
    5. The efficacy of the combination of topical minoxidil and oral spironolactone compared with the combination of topical minoxidil and oral finasteride in women with androgenic alopecia, female and male hair loss patterns: A blinded randomized clinical trial Journal of Cosmetic Dermatology · 2023
    6. The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review Clinical, Cosmetic and Investigational Dermatology · 2023
    7. Topical Finasteride versus Topical Spironolactone in the Treatment of Androgenetic Alopecia The Medical Journal of Cairo University · 2020
    8. Lack of endocrine systemic side effects after topical application of spironolactone in man Journal of endocrinological investigation · 1988 · 8 citations
    9. Assessment of the efficacy of topical antiandrogen; spironolactone in patients with androgenetic alopecia by dermoscopy Journal of Pakistan Association of Dermatologists · 2022
    10. A novel topical combination of minoxidil and spironolactone for androgenetic alopecia: Clinical, histopathological, and physicochemical study Dermatologic Therapy · 2020 · 10 citations
    11. Clinical and Trichoscopic Evaluations of Topical Finasteride 1%, Topical Spironolactone 5%, and Minoxidil 5% in Female Pattern Hair Loss Treatment Dermatology Practical & Conceptual · 2025
    12. Evaluation of the Efficacy and Safety of Topical Spironolactone versus Topical Minoxidil in the Treatment of Female Pattern Hair Loss: A Comparative, Clinical, and Trichoscopic Study International Journal of Trichology · 2025
    13. Dermoscopic evaluation of the efficacy of combination of topical spironolactone 5% and minoxidil 5% solutions in the treatment of androgenetic alopecia, comparative study. Al-Azhar International Medical Journal (Print) · 2022
    14. A Systematic Review of Spironolactone Nano-Formulations for Topical Treatment of Skin Hyperandrogenic Disorders and Chronic Wounds Pharmaceutics · 2024
    15. Comparative study between topical minoxidil 5% and oral spironolactone versus topical minoxidil 5% and oral dutasteride in the treatment of women with androgenic alopecia International Journal of Medical Arts · 2026
    16. Evaluation of the efficacy of topical spironolactone 5% solution versus minoxidil 5% solution vs combination of topical spironolactone 5% and minoxidil 5% solutions in female pattern hair loss International Journal of Medical Arts · 2026
    17. Spironolactone for the Treatment of Acne: A 4-Year Retrospective Study Dermatology · 2017 · 22 citations
    18. Spironolactone and XPB: An Old Drug with a New Molecular Target Biomolecules · 2020 · 18 citations
    19. Topical solutions for androgenetic alopecia: evaluating efficacy and safety Forum Dermatologicum · 2024
    20. Treatment of female pattern hair loss with a combination of spironolactone and minoxidil Australasian Journal of Dermatology · 2007 · 21 citations
    21. Topical Antiandrogens Archives of Dermatology · 1985 · 11 citations
    22. High-dose spironolactone for acne in patients with polycystic ovarian syndrome: A single-institution retrospective study Journal of The American Academy of Dermatology · 2019 · 3 citations
    23. Topical Finasteride Therapy in Hirsutism Endocrine Practice · 2001 · 1 citations
    24. Efficacy and safety of spironolactone versus bicalutamide in female pattern hair loss: A retrospective comparative study Australasian journal of dermatology · 2024
    25. New Topical Treatment for Psoriasis Journal of exploratory research in pharmacology · 2023
    26. Optimal use of topical minoxidil in management of female pattern hair loss in India: an expert opinion International Journal of Research in Dermatology · 2022
    27. The tyranny of distance Clinical Cosmetic and Investigational Dermatology · 2011
    28. S123 The pathological dynamics of androgenetic alopecia and its treatment Journal of The European Academy of Dermatology and Venereology · 1997
    29. Androgenic alopecia: an entity to consider in adolescence Case Reports · 2017 · 6 citations
    30. Female Progressive Scalp Hair Loss Associated with Ovarian Thecoma Skin appendage disorders · 2019