Facial Contact Dermatitis Due to Spironolactone in an Anti-Acne Cream

November 1993 in “ Contact dermatitis ”

Colombina Vincenzi, Pompilio Trevist, Paolo Farina, Caterina Stinchi, Antonella Tosti

spironolactone contact dermatitis anti-acne cream systemic corticosteroids patch testing eczema eczema corticosteroids

TLDR Spironolactone in anti-acne cream can cause allergic skin reactions in some people.

In this 1993 study, a 29-year-old woman developed facial contact dermatitis after using a 5% spironolactone anti-acne cream for 2 months. Initially, her acne improved, but she later experienced an itchy eczematous eruption. Patch testing confirmed an allergic reaction to spironolactone. The dermatitis resolved after discontinuing the cream and treating with systemic corticosteroids. This case highlighted the potential for spironolactone to cause contact dermatitis, despite its effectiveness and general safety in topical applications. Further patch tests on 20 healthy volunteers showed no reactions, suggesting individual sensitivity.

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Research cited in this study

3 / 3 results

research Lack of Endocrine Systemic Side Effects After Topical Application of Spironolactone in Men

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Topical spironolactone cream doesn't cause hormone-related side effects in the body.

research Lack of Effect of a Spironolactone-Containing Cream on Hair Growth in Hirsute Women

16 citations, January 1987 in “Dermatology”

The spironolactone cream did not reduce hair growth in women with hirsutism.

research Topical Antiandrogens

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Facial Contact Dermatitis Due to Spironolactone in an Anti-Acne Cream

Research cited in this study

research Lack of Endocrine Systemic Side Effects After Topical Application of Spironolactone in Men

research Lack of Effect of a Spironolactone-Containing Cream on Hair Growth in Hirsute Women

research Topical Antiandrogens

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