Diphenyl Ethers as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production

    April 2009 in “ Bioorganic & Medicinal Chemistry Letters ”
    Lorna Helen Mitchell, Lain-Yen Hu, Maria Nguyen … Bruce Allen Lefker
    Studysummary Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.
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    Research cited in this study 5

    1. 4-(Alkylthio)- and 4-(Arylthio)-Benzonitrile Derivatives as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production Bioorganic & Medicinal Chemistry Letters · 2009
    2. (1R,2S)-4-(2-Cyano-Cyclohexyl-Oxy)-2-Trifluoromethyl-Benzonitrile, A Potent Androgen Receptor Antagonist For Stimulating Hair Growth And Reducing Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007
    3. Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007
    4. Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007
    5. Treatment of Androgenic Disorders in Women: Acne, Hirsutism, and Alopecia Cleveland Clinic journal of medicine · 1990

    Related research 2

    1. Diphenyl Ethers as Androgen Receptor Antagonists for the Topical Suppression of Sebum Production Bioorganic & Medicinal Chemistry Letters · 2009
    2. Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007