TLDR Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.
In 2009, Pfizer Global Research and Development conducted a study on the use of diphenyl ethers as androgen receptor antagonists to suppress sebum production, which is linked to conditions like acne and alopecia. The research found that diphenyl ethers, when applied topically, could bind to the androgen receptor and reduce sebum production. The study prepared and evaluated a series of diphenyl ethers for their androgen receptor antagonist activity. Several compounds, particularly 1, 2, and 6i, showed over 80% reduction of wax esters, a component of sebum, in a Golden Syrian Hamster ear model when applied as a 3% topical formulation. The study concluded that diphenyl ethers could potentially be used as topical treatments for conditions related to excess sebum production.
Cited in this study
5 / 5 results
11 citations
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March 2009 in “Bioorganic & Medicinal Chemistry Letters” Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.
14 citations
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November 2007 in “Bioorganic & Medicinal Chemistry Letters” The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.
17 citations
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October 2007 in “Bioorganic & Medicinal Chemistry Letters” A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.
11 citations
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October 2007 in “Bioorganic & Medicinal Chemistry Letters” Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.
19 citations
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July 1990 in “Cleveland Clinic journal of medicine” Androgen excess disorders in women were effectively treated with spironolactone, estrogen, and dexamethasone.
7 citations
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April 2009 in “Bioorganic & Medicinal Chemistry Letters” Diphenyl ethers can potentially reduce excess oil production when applied on the skin, helping treat conditions like acne.
17 citations
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October 2007 in “Bioorganic & Medicinal Chemistry Letters” A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.
