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GlossaryHepatocytes

primary functional cells of the liver involved in metabolism

Hepatocytes are the primary functional cells of the liver, making up about 70-80% of the liver's mass. They play a crucial role in various metabolic processes, including detoxification, protein synthesis, and the production of biochemicals necessary for digestion, such as bile.

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research In Vitro Expansion of Human Mesenchymal Stem Cells and Hepatocytes Using Purified Platelet-Derived Growth Factors: A Potential Therapeutic Modality for Liver Fibrosis

April 2023 in “Egyptian journal of Immunology”

10% hPL is best for growing mesenchymal stem cells, while 10% FBS is best for hepatocytes.

research Regulation of the Metabolic Phenotype of Human Hepatocytes by Glucocorticoids and Androgens

December 2016 in “University of Birmingham Institutional Research Archive (University of Birmingham)”

Glucocorticoids reduce fat production in liver cells, while androgens increase it in females; manipulating certain enzymes can influence these effects.

research Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture

249 citations , November 2018 in “Cell”

TNFα helps grow and maintain liver cells in 3D culture for a long time.

research 5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes

54 citations , May 2015 in “Endocrinology”

Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.

research Role of S-Palmitoylation by ZDHHC13 in Mitochondrial Function and Metabolism in Liver

59 citations , May 2017 in “Scientific reports”

ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.

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in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

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in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

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in Research/Science 2453 upvotes 4 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community Opinions on this study for Triphasic Progressive by Rene Furterer

in Research/Science 14 upvotes 2 years ago

The user shared their 5-year hair loss journey, initially using a product called Triphasic Progressive by Rene Furterer, which gave good results. Later, they switched to FDA-approved medications finasteride and minoxidil, which also helped, but they noticed the most significant progress with Triphasic. They're considering trying it again if minoxidil doesn't show improvements.