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GlossaryHepatocytes

primary functional cells of the liver involved in metabolism

Hepatocytes are the primary functional cells of the liver, making up about 70-80% of the liver's mass. They play a crucial role in various metabolic processes, including detoxification, protein synthesis, and the production of biochemicals necessary for digestion, such as bile.

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research Regulation of the Metabolic Phenotype of Human Hepatocytes by Glucocorticoids and Androgens

December 2016 in “University of Birmingham Institutional Research Archive (University of Birmingham)”

Glucocorticoids reduce fat production in liver cells, while androgens increase it in females; manipulating certain enzymes can influence these effects.

research Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture

249 citations , November 2018 in “Cell”

TNFα helps grow and maintain liver cells in 3D culture for a long time.

research 5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes

54 citations , May 2015 in “Endocrinology”

Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.

research Role of S-Palmitoylation by ZDHHC13 in Mitochondrial Function and Metabolism in Liver

59 citations , May 2017 in “Scientific reports”

ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.

research Mechanisms of Hepatocyte Attachment to Keratin Biomaterials

53 citations , July 2011 in “Biomaterials”

Human liver cells stick to hair protein materials mainly through the liver's asialoglycoprotein receptor.

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community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community The theory that explains everything. Please help me make this big!

in Research/Science 2451 upvotes 4 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community Opinions on this study for Triphasic Progressive by Rene Furterer

in Research/Science 14 upvotes 2 years ago

The user shared their 5-year hair loss journey, initially using a product called Triphasic Progressive by Rene Furterer, which gave good results. Later, they switched to FDA-approved medications finasteride and minoxidil, which also helped, but they noticed the most significant progress with Triphasic. They're considering trying it again if minoxidil doesn't show improvements.