ERALOP Study: Post Adjuvant FEC-Docetaxel Chemotherapy for Early Breast Cancer: Hair Regrowth in Real Life

    May 2015 in “ Cancer research ”
    Hugues Bourgeois, A. Jamet, F. Grudé, Carole Adounkpe, Pierre Kerbrat, R. Delva, H. Simon, Philippe Deguiral, Bertrand Diquet, Pascale Lainé, Anne-Lise Septans
    TLDR After chemotherapy for early breast cancer, 33.4% of patients had long-term significant hair loss, with some hair regrowth over time, but treatments for hair loss were largely ineffective.
    The ERALOP study, conducted in 2015, retrospectively examined the incidence of persistent significant alopecia (PSA) in 829 patients who underwent FEC 100-docetaxel 100 mg/msq chemotherapy for early breast cancer between 2008 and 2009. Six months after the last docetaxel course, 8.6% of patients experienced grade 2 PSA (hair loss > 50% with a psychosocial impact), 32.6% had grade 1 PSA (hair loss of up to 50%), and 56% had no PSA. At the time of the inquiry (median follow-up of 3.7 years), the global PSA incidence was 33.4%. Between 6 months after the last docetaxel course and the time of the inquiry, slight or total hair regrowth was observed in patients with PSA grade 2 and 1. However, many patients experienced suboptimal regrowth of eyelash (31%), eyebrow (47%), pubic hair (27%), and nail disorders (27%). All oral treatments tested, including dexpanthenol, biotin, methionine cysteine, and cystin-vitamin B6, showed no efficacy, while topical minoxidil showed slight efficacy. The high level of PSA led to the ALOPREV trial to investigate the use of a cooling cap during docetaxel infusion to prevent alopecia.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 267 results

      community M26 - 9 months after hair transplant! AMA

      in Transplants  624 upvotes 5 years ago
      A user who underwent a hair transplant in Istanbul to reduce balding, and the discussion of various treatments such as finasteride and growth hormone for preventing further hair loss.

      community 1 month Pyrilutamide. A non responders story to everything.

      in Research/Science  218 upvotes 2 years ago
      My hairline, I am only 23. This conversation is about a user's experience with treatments for androgenic alopecia, including finasteride, dutasteride, RU, minoxidil, progesterone, melatonin, LLLT, oral minoxidil, and Pyrilutamide. They have tried many treatments over the course of two years without seeing much success, and they are considering getting a hair system as a last resort.

      community Are Derma Rollers Actually Harmful in the Long Run?

      in Microneedling  40 upvotes 1 month ago
      Derma rollers may cause scarring alopecia, leading some to prefer dermastamps or dermapens for microneedling. Combining minoxidil with microneedling is effective, but proper technique and healing time are essential to prevent damage.

      community What 3 months without fin& min does😔

      in Progress Pictures  261 upvotes 5 months ago
      Stopping minoxidil and finasteride for three months caused significant hair loss. The user resumed treatment with 2.5mg oral minoxidil and 0.6mg finasteride and plans to update on progress in three months.

    Similar Research

    5 / 1000+ results