ERALOP Study: Post Adjuvant FEC-Docetaxel Chemotherapy for Early Breast Cancer: Hair Regrowth in Real Life

    May 2015 in “ Cancer research ”
    Hugues Bourgeois, A. Jamet, F. Grudé, Carole Adounkpe, Pierre Kerbrat, R. Delva, H. Simon, Philippe Deguiral, Bertrand Diquet, Pascale Lainé, Anne-Lise Septans
    TLDR After chemotherapy for early breast cancer, 33.4% of patients had long-term significant hair loss, with some hair regrowth over time, but treatments for hair loss were largely ineffective.
    The ERALOP study, conducted in 2015, retrospectively examined the incidence of persistent significant alopecia (PSA) in 829 patients who underwent FEC 100-docetaxel 100 mg/msq chemotherapy for early breast cancer between 2008 and 2009. Six months after the last docetaxel course, 8.6% of patients experienced grade 2 PSA (hair loss > 50% with a psychosocial impact), 32.6% had grade 1 PSA (hair loss of up to 50%), and 56% had no PSA. At the time of the inquiry (median follow-up of 3.7 years), the global PSA incidence was 33.4%. Between 6 months after the last docetaxel course and the time of the inquiry, slight or total hair regrowth was observed in patients with PSA grade 2 and 1. However, many patients experienced suboptimal regrowth of eyelash (31%), eyebrow (47%), pubic hair (27%), and nail disorders (27%). All oral treatments tested, including dexpanthenol, biotin, methionine cysteine, and cystin-vitamin B6, showed no efficacy, while topical minoxidil showed slight efficacy. The high level of PSA led to the ALOPREV trial to investigate the use of a cooling cap during docetaxel infusion to prevent alopecia.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 401 results

      community How is dht not beneficial to you?

      in Finasteride/Dutasteride  111 upvotes 1 month ago
      DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

      community M26 - 9 months after hair transplant! AMA

      in Transplants  624 upvotes 6 years ago
      A user who underwent a hair transplant in Istanbul to reduce balding, and the discussion of various treatments such as finasteride and growth hormone for preventing further hair loss.

      community 4 month is in - 2 pics - fin/min+

      in Progress Pictures  386 upvotes 1 year ago
      The user shared a 4-month update on their hair regrowth journey using finasteride, minoxidil, and microneedling, reporting significant progress and styling ability. They emphasized persistence, shared their regimen details, and addressed side effects like weaker erections and blurry vision, which improved with lifestyle changes.

      community Diffuse thinning is the worst man

      in Chat  248 upvotes 2 years ago
      The conversation is about the struggles of dealing with diffuse thinning at a young age and the lack of significant improvement after using treatments like finasteride and minoxidil. Some suggest additional methods like derma rolling, microneedling, and hair fibers, while others share their own experiences and encourage persistence with treatment.

    Similar Research

    5 / 1000+ results