Total Prostate Volume as Risk Factor for Semen Pathologies in Aging Male

    October 2010 in “ Journal of Men's Health ”
    AusmeesK., ZarkovskiM., TimbergG., KorrovitsP., PunabM.
    Image of study
    TLDR Larger prostate size in older men may be linked to poorer semen quality and fertility issues.
    The study investigated the relationship between semen quality, lower urinary tract symptoms (LUTS), and prostate volume in aging men. A total of 316 men aged 45-67 were examined, with semen samples assessed according to WHO guidelines. The study found that sperm concentration and motility negatively correlated with total prostate volume and LUTS, while testicular size positively correlated with sperm concentration and motility. Additionally, seminal plasma interleukin-6 levels positively correlated with total prostate volume and PSA levels. The results suggest that semen pathologies and reduced fertility rates may be associated with LUTS and prostate diseases in aging men. However, future research is needed to directly define these relationships and examine the treatment effects of LUTS on fertility rates. The document also discusses the potential persistent adverse effects of 5α-reductase inhibitors, used to treat androgenetic alopecia and benign prostatic hypertrophy, on sexual function, depression, and quality of life, suggesting that physicians should exercise caution and thoroughly discuss these issues with patients before prescribing this therapy.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 90 results

      community Hair Loss Drugs Ranked in Order of Efficacy

      in Research/Science  67 upvotes 11 months ago
      Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.

      community 1 month of using fin, so happy

      in Progress Pictures  863 upvotes 3 months ago
      User had a hair transplant and used a finasteride and minoxidil spray for 6 months with no results. After adding finasteride tablets for 1 month, they saw significant hair growth improvement.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 2 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Another clueless guy fearmongering and spreading misinformation

      in Chat  251 upvotes 9 months ago
      The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.

    Similar Research

    5 / 1000+ results