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    Glossary Substance P

    neuropeptide involved in pain perception and inflammation

    Substance P (SP) is a neuropeptide that functions as a neurotransmitter and neuromodulator, playing a key role in pain perception by transmitting pain signals to the central nervous system. It is also involved in inflammatory processes and can influence hair growth by affecting the local immune response and blood flow in the scalp.

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    1. Stress Inhibits Hair Growth in Mice by Induction of Premature Catagen Development and Deleterious Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways American Journal of Pathology · 2003 · 194 citations
    2. Indications for a brain‐hair follicle axis: inhibition of keratinocyte proliferation and up‐regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P The FASEB Journal · 2001 · 125 citations
    3. Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice PLoS ONE · 2013 · 76 citations
    4. Influence of substance-P on cultured sebocytes Archives of Dermatological Research · 2008 · 46 citations
    5. Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin PLOS ONE · 2013 · 24 citations
    6. New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP<sub>3</sub>‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75<sup>NTR</sup>and TrkA) in<i>ex vivo</i>human male androgenetic scalp hair follicles British Journal of Dermatology · 2020 · 12 citations
    7. Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P–induced human mast cell activation and degranulation in the hair follicle The Journal of Allergy and Clinical Immunology · 2018 · 8 citations
    8. Substance P prolongs human hair growth in vitro Journal of dermatological science · 2003 · 8 citations
    9. Substance P in keratosis follicularis spinulosa decalvans JAAD case reports · 2015 · 4 citations
    10. Effects of Guasha on histomorphology of scraped skins and on expression of calcitonin gene-related peptide and substance P in rats Deleted Journal · 2018 · 3 citations
    11. Effects of Substance P on the Expression of Various Factors to control Hair Growth in Human Hair Follicle Culture Linchuang pifuke zazhi · 2004 · 1 citations
    12. Evaluation of serum substance P,folic acid and ferritin in female patients with hair fall and trichodynia ALEXMED ePosters · 2025
    13. Tissue and serum levels of substance P in trichodynia of androgenetic alopecia patients Journal of the Egyptian Womenʼs Dermatologic Society · 2025
    14. 653 Substance P ameliorates epidermal thickness, basal cell density, and asymmetric stem cell self-renewal in skin with decreased sensory innervation Journal of Investigative Dermatology · 2024
    15. LB1017 A novel link between human hair follicle neuroimmunology and mitochondrial biology: Substance P increases intrafollicular oxidative stress and mitochondrial biogenesis Journal of Investigative Dermatology · 2022
    16. Reduced rates of substance use disorder in patients with alopecia: An all of us case-control study Archives of Dermatological Research · 2024 · 1 citations
    17. Substances declared as active ingredients in topical anti-hair loss products – a review of the evidence for their effectiveness in light of clinical studies Homo Politicus (Academy of Humanities and Economics in Lodz) · 2026
    18. Cutaneous manifestations associated with substance use disorders JAAD reviews. · 2025
    19. BIOACTIVE SUBSTANCE OF MEDICINAL PLANTS EFFECTIVE AGAINST HAIR LOSS International Journal of Biological Innovations · 2025
    20. The synergistic effect of phototherapy and active substances on hair growth Journal of Photochemistry and Photobiology B Biology · 2024
    21. Associations of prenatal and postnatal exposure to perfluoroalkyl substances with pubertal development and reproductive hormones in females and males: The HOME study Science of the total environment · 2023 · 5 citations
    22. Prenatal and prepubertal exposures to organochlorine compounds and perfluoroalkyl substances and pubertal development at age 12: The PELAGIE cohort study Environment International · 2025
    23. Androgenetic alopecia, trichotrophic substances, and histologic studies of the human scalp Clinics in Dermatology · 1988 · 5 citations
    24. Extractable substances from human hair: a discussion about the origin of the holes Colloids and surfaces. B, Biointerfaces · 2004 · 15 citations
    25. A Fast and Efficient UPLC-ESI-MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts of Preventing Hair Loss Bulletin of the Korean Chemical Society · 2015 · 4 citations
    26. Severe Lichen Planus Pigmentosus Inversus in an Elderly Female Following Intra-Articular Injections of Homeopathic Substances Dermato · 2026
    27. What should it take to describe a substance or product as 'sperm-safe' Human Reproduction Update · 2013 · 58 citations
    28. Immunochemical studies on blood group A substance from human hair International Journal of Legal Medicine · 1977 · 6 citations
    29. Synergistic Innovative Therapies in Dermatology: Integrating Platelet Derivatives, Biomaterials, and Exogenous Bioactive Substances for Enhancing Skin Repair and Regeneration Drug Design Development and Therapy · 2025
    30. Effet de la consommation de régimes carencés en iode ou contenant de substances goitrigènes ou supposées sur la croissance pondérale de rats Wistar International journal of biological and chemical sciences · 2022 · 1 citations