Tissue And Serum Levels Of Substance P In Trichodynia Of Androgenetic Alopecia Patients

    Yasser Mostafa Gohary, Olfat G. Shaker, Lina Adel ElShimy, Sarah Osman
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    TLDR Higher substance P levels may cause discomfort in hair loss patients.
    The study involving 70 participants (35 with trichodynia in androgenetic alopecia and 35 healthy controls) found that substance P (SP) levels were significantly higher in AGA patients, with a positive correlation between tissue SP levels and trichodynia severity. This suggests SP's involvement in the pathogenesis of trichodynia in AGA patients, indicating its potential role in the discomfort associated with the condition. Further large-scale studies are recommended to explore SP's role in AGA and potential treatments for trichodynia.
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