Effects of Guasha on Histomorphology of Scraped Skin and Expression of Calcitonin Gene-Related Peptide and Substance P in Rats

The study investigated the effects of Guasha, a traditional Chinese scraping therapy, on the skin and the expression of calcitonin gene-related peptide (CGRP) and substance P (SP) in 50 rats. The rats were divided into five groups for observation at different time points after their dorsal setae were shaved and Guasha was performed on one side of the spine. The results showed that Guasha caused significant changes in the appearance, hair follicles, and blood vessels of the scraped skin compared to the control group. However, these changes returned to normal within five days. Additionally, Guasha did not significantly alter the expression of CGRP and SP or the morphology of nerve fibers in the skin.