A Mechanism for Topical Cutaneous Calcinosis

    December 1973 in “ Calcified tissue research ”
    Fred Leonard, Andrew F. Hegyeli
    TLDR Epilation and DHT cause skin calcification by increasing ATP and calcium deposits.
    The study proposed a mechanism for topical cutaneous calcinosis based on findings that ATP levels were higher in epilated rats compared to non-epilated ones. The hypothesis suggested that feeding DHT caused generalized hypercalcemia, and subsequent epilation led to tissue trauma, increasing cell membrane permeability and ATP release. The resulting CaATP hydrolyzed to form calcium orthophosphate, which acted as a nucleating seed for calcification. The necessary ground substance for plaque formation included collagen fibers and mucopolysaccharides in the dermal layer or hair follicle.
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