A Mechanism for Topical Cutaneous Calcinosis

    December 1973 in “ Calcified tissue research ”
    Fred Leonard, Andrew F. Hegyeli
    TLDR Epilation and DHT cause skin calcification by increasing ATP and calcium deposits.
    The study proposed a mechanism for topical cutaneous calcinosis based on findings that ATP levels were higher in epilated rats compared to non-epilated ones. The hypothesis suggested that feeding DHT caused generalized hypercalcemia, and subsequent epilation led to tissue trauma, increasing cell membrane permeability and ATP release. The resulting CaATP hydrolyzed to form calcium orthophosphate, which acted as a nucleating seed for calcification. The necessary ground substance for plaque formation included collagen fibers and mucopolysaccharides in the dermal layer or hair follicle.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Scientific evidence for Peppermint & Rosemary oils + My Experience

      in Research/Science  114 upvotes 1 year ago
      Natural treatments for hair loss, specifically peppermint oil and rosemary oil; how they can be used as a supplementary or alternative treatment to pharmaceuticals such as finasteride and minoxidil; and the personal experience of the user Divallo, who has seen an increase in density and thickness after using these oils for around 2.5 years. The post also touches on the potential antifungal properties of the oils and their effects on cutaneous blood flow.

      community Homemade topical spironolactone

      in Research/Science  26 upvotes 2 years ago
      The potential effectiveness of homemade topical spironolactone in treating hair loss, with studies suggesting it is more effective than finasteride and even minoxidil when used as monotherapy. The conversation also mentions that other anti-androgens are being developed which may soon hit the market.

      community Went from almost balding to some this!

      in Progress Pictures  498 upvotes 10 months ago
      A user successfully regrew hair after nearly going bald by using oral finasteride, topical minoxidil, plasma injections, and mesotherapy over 9 months. They plan to try derma rolling and have an alarm set for taking medication, noting increased sexual drive as a side effect.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  65 upvotes 1 year ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community high bloodpressure and crown thinning in early 20s

      in Is this regrowth?  9 upvotes 5 months ago
      A user with kidney disease and high blood pressure experienced hair thinning, especially around the vertex. They are currently using finasteride and oral minoxidil but are considering whether to resume blood pressure medication despite managing symptoms with diet and exercise.

      community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

      in Research/Science  108 upvotes 1 year ago
      Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

    Similar Research

    5 / 1000+ results