TLDR Hair follicle tissue can induce mineral formation, likely due to a potent nucleator.
The study from 1973 investigated the mineralization of hair follicle tissue in calcium phosphate solutions, revealing that uninjured hair follicle tissue could effectively induce mineral formation at low supersaturation levels, suggesting the presence of a potent nucleator of calcium phosphate. This nucleator might have been responsible for the initial localization of mineral deposits during skin calcification in vivo. Hair clippings without follicle tissue showed limited nucleating ability. The nucleating ability of lyophilized and stored follicle tissue was lost but could be partially restored with mercaptoethanol, indicating the involvement of sulfhydryl groups. The mineral precipitated was nodular and contained octacalcium phosphate and hydroxyapatite, as shown by X-ray diffraction. Soluble follicle proteins inhibited crystal growth and secondary nucleation, differing from the nucleation by insoluble follicle proteins.
7 citations
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December 1971 in “Calcified Tissue Research” Hair follicles in injured skin can quickly accumulate minerals, especially calcium and phosphorus.
12 citations
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December 1965 in “Immunology and Cell Biology” Mild skin injury can trigger mineral deposits in rat skin, even without full calciphylactic response.
82 citations
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November 1959 in “Annals of the New York Academy of Sciences” 11 citations
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January 1957 in “Journal of Histochemistry & Cytochemistry” Ca 45 mainly enters rat skin and eye through biosynthesis and may be adsorbed in cartilage and glands.
5 citations
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August 2011 in “Journal of Dermatological Science” Dentin sialoprotein and phosphophoryn are present in rodent hair follicles and may help hair growth and development.
2 citations
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December 1973 in “Calcified tissue research” Epilation and DHT cause skin calcification by increasing ATP and calcium deposits.
57 citations
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June 2021 in “Polymers” Photothermal hydrogels are promising for infection control and tissue repair, and combining them with other treatments could improve results and lower costs.
1533 citations
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October 2008 in “Endocrine reviews” Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.
41 citations
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December 2019 in “Stem Cell Reviews and Reports” Tooth regeneration could become possible by controlling how and when bioactive factors are released.
