Expression of Mineralized Tissue Associated Proteins: Dentin Sialoprotein and Phosphophoryn in Rodent Hair Follicles

    August 2011 in “ Journal of Dermatological Science ”
    Xu Tang, Ya-Qin Zhu, Cynthia L. Marcelo, Helena H. Ritchie
    TLDR Dentin sialoprotein and phosphophoryn are present in rodent hair follicles and may help hair growth and development.
    The study investigated the expression of mineralized tissue-associated proteins, specifically dentin sialoprotein (DSP) and phosphophoryn (PP), in rodent hair follicles. Researchers used immunohistochemistry, in situ hybridization, and transgenic mice to confirm the presence of these proteins in hair follicles, suggesting they might contribute to hair follicle development and potentially to the mineralization and hardness of the hair root sheath. The findings indicated common developmental pathways between teeth and hair follicles, providing new insights into the molecular mechanisms underlying hair growth and development.
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