Skin and Hair Regeneration After Calciphylaxis: Histologic Changes During Formation and Shedding of the Calciphylactic Carapace in Rats

The study conducted a detailed histologic analysis of localized calciphylaxis in rat skin, revealing that the calcified carapace did not contain the complete skin, allowing for some regeneration from the remaining connective tissue and epithelium. However, the regeneration was incomplete, resembling scar tissue, with a significant reduction in the number of hairs and no restoration of elastic fibers. It was unclear whether the regrowth of hairs was due to surviving hair roots or true neogenesis. Additionally, there was a notable increase in calcium in growing hairs and a lack of alcian blue stainable substances in mast cell granules after calciphylaxis.