Substance P in Keratosis Follicularis Spinulosa Decalvans

    September 2015 in “ JAAD case reports ”
    Isabella Doche, Maria Hordinsky, George L. Wilcox, Neusa Yuriko Sakai Valente, Ricardo Romiti
    TLDR Substance P may play a role in the inflammation seen in keratosis follicularis spinulosa decalvans.
    The study described a 10-year-old Brazilian girl with keratosis follicularis spinulosa decalvans (KFSD), a rare inherited disorder characterized by scarring alopecia and keratosis pilaris. The patient exhibited severe pruritus and increased levels of Substance P (SP) in the scalp, particularly in the most affected areas. Histopathologic analysis showed perifollicular lymphocytic inflammation and fibrosis. The findings suggested that SP might play a role in the pruritus and inflammation associated with KFSD, indicating a need for further research into neurogenic inflammation and potential treatments targeting SP, such as NK-1R antagonists.
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