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GlossaryPerifollicular Inflammation

swelling and irritation around hair follicles

Perifollicular inflammation refers to the swelling and irritation that occurs around hair follicles. This condition can lead to hair loss and is often seen in various types of alopecia, such as alopecia areata. It involves immune cells attacking the hair follicles, which can disrupt normal hair growth and cause damage to the follicle structure.

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Perifollicular Inflammation and Fibrosis in Androgenetic Alopecia: Implications for Diagnosis and Treatment - A Comparative Histopathologic and Clinical Study with Normal-Appearing Scalp

research Perifollicular Inflammation and Fibrosis in Androgenetic Alopecia: Implications for Diagnosis and Treatment - A Comparative Histopathologic and Clinical Study with Normal-Appearing Scalp

January 2026 in “Clinical Cosmetic and Investigational Dermatology”

Early diagnosis and targeted anti-inflammatory treatments can improve outcomes in androgenetic alopecia with perifollicular inflammation and fibrosis.

research A Case of Inflammatory Nonscarring Alopecia Associated With the Tyrosine Kinase Inhibitor Nilotinib

16 citations , March 2013 in “JAMA Dermatology”

A cancer drug called nilotinib might cause hair loss due to inflammation around hair follicles.

research Substance P in Keratosis Follicularis Spinulosa Decalvans

4 citations , September 2015 in “JAAD case reports”

Substance P may play a role in the inflammation seen in keratosis follicularis spinulosa decalvans.

research Fibrosing Alopecia in a Pattern Distribution

April 2012 in “Informa Healthcare eBooks”

Fibrosing alopecia in a pattern distribution is a unique hair loss condition with inflammation and scarring, resembling but distinct from common balding.

Histopathological Findings of Uncomplicated Hair Transplant for Male Androgenetic Alopecia: Can Lichen Planopilaris Features Be Present?

research Histopathological Findings of Uncomplicated Hair Transplant for Male Androgenetic Alopecia: Can Lichen Planopilaris Features Be Present?

1 citations , January 2020 in “Skin appendage disorders”

Hair transplants for male baldness can show inflammation and fibrosis, but more research is needed to confirm LPP presence.

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community Lost density 60% all over scalp in 120 days (4months)

in Update 10 upvotes 1 year ago

A user lost 60% hair density in 4 months, started finasteride and microneedling, and has greasy, flaky, yellowish scalp. They are awaiting biopsy results, and another user suggested trying ketoconazole shampoo.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 416 upvotes 10 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 52 upvotes 1 year ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Perifollicular Fibrosis and its role in androgenetic alopecia. Is Aminexil/Kopexil a must for anyone with AGA?

in Research/Science 4 upvotes 3 years ago

Aminexil/Kopexil may help reduce hair loss by addressing perifollicular fibrosis in androgenetic alopecia, but it lacks the extensive clinical backing of finasteride and minoxidil. Some users find it effective, but availability and cost are issues, especially in the US where it's not FDA-approved.

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