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GlossarySubstance P

neuropeptide involved in pain perception and inflammation

Substance P (SP) is a neuropeptide that functions as a neurotransmitter and neuromodulator, playing a key role in pain perception by transmitting pain signals to the central nervous system. It is also involved in inflammatory processes and can influence hair growth by affecting the local immune response and blood flow in the scalp.

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community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Neck tension, and hair loss, I am 100 percent sure that there is a connection

in Treatment 19 upvotes 6 months ago

The user believes neck tension and poor posture contribute to hair loss, noticing improvements with yoga and muscle relaxation. Replies suggest androgenic alopecia as the cause and recommend exercises.

community Is anyone taking creatine while on fin and/or dut?

in Finasteride/Dutasteride 33 upvotes 4 months ago

The conversation discusses the use of creatine while on finasteride and/or dutasteride for hair loss. Opinions vary, with some users reporting no issues and others experiencing accelerated hair loss, suggesting effects are individual.

community Shrooms have done more for my hair loss than all of my hair supplements/medications combined.

in Satire 408 upvotes 1 year ago

Finding acceptance of hair loss through psychedelics, and the potential benefits of shrooms. Discussions include sharing experiences with minoxidil, finasteride, nutrafol, laser therapy, micro needling, as well as mental health concerns such as depression, suicidal thoughts, and self-esteem.

community Excited to stack Finasteride+Kx826 😃

in Research/Science 37 upvotes 3 months ago

The conversation is about using finasteride and KX826 for hair loss treatment. The original poster is using 0.25 mg of finasteride every other day due to side effects at a higher dose.

community Is topical finasteride as effective as oral finasteride?

in Finasteride/Dutasteride 6 upvotes 4 months ago

Topical finasteride is almost as effective as oral finasteride with fewer side effects. Users are considering between oral and topical finasteride for hair loss treatment.

community Been doing daily 3% topical peppermint oil for 6+ months (never used minoxidil). Have had growth that seems as good as minoxidil. Might strenghten the idea that peppermint is a good low-cost treatment, that potentially works by another route than minoxidil.

in Treatment 15 upvotes 2 years ago

The user has been using finasteride, nizoral, microneedling, and recently added 3% peppermint oil to their hair loss treatment, experiencing regrowth similar to minoxidil. They suggest peppermint oil as a potentially effective, low-cost alternative or addition to minoxidil, with the added benefit of a pleasant smell and ease of use.

community Found it. Sulforaphane, a phytochemical in broccoli sprouts, promotes hair growth (60% regeneration in mice) by accelerating the degradation of DHT.

112 upvotes 7 years ago

Sulforaphane, found in broccoli sprouts, promotes hair growth by degrading DHT. Users discuss its potential benefits and joke about unconventional application methods.

community How is there no topical anti-androgen that doesn’t go systematic?!

in Treatment 6 upvotes 4 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, RU58841, Alfatradiol, and Eucapil. Topical treatments must penetrate skin and may go systemic, with effectiveness varying.

community I'm experiencing significant growth with unknown substance(s). I want to know which one it is.

in Product 8 upvotes 1 year ago

A user from Iran reports hair growth in bald spots after using a domestic tonic containing Anageline, Trichogen, Aminexil, Caffeine, Saw Palmetto, and B vitamins, alongside Finasteride, but without Minoxidil. They prefer the tonic over Minoxidil as it doesn't make their hair greasy or cause hair fall.

community A little perspective from Bill Burr

6 upvotes 11 years ago

The user has been using Propecia for about 11 months and believes it has slowed hair loss. They acknowledge likely future hair loss and emphasize the value of a positive attitude.

community Kintor pyrilutamide presentation?

in Research/Science 12 upvotes 2 years ago

The conversation is about whether the phase 2 results for pyrilutamide, a potential hair loss treatment, were presented at a dermatology convention and inquiries about the completion of phase 3 trials. Specific treatments mentioned include pyrilutamide.

community RU58841 powder from lab supplier tested at free drug testing service

in Treatments 207 upvotes 3 months ago

RU58841 powder from a lab supplier was tested at a free drug testing service. The discussion includes using Minoxidil and finasteride for hair loss treatment.

community Soundwaves & Electricity Grows Hair? | Peptide Delivery Model.

in Research/Science 2 upvotes 3 months ago

Iontophoresis and sonophoresis can enhance drug delivery into the scalp. Combining these methods may improve the effectiveness of topical treatments like dutasteride and certain peptides.

community MY 6 MONTH TRANSFORMATION PROGRESS

in Progress Pictures 210 upvotes 4 months ago

A 23-year-old male shared his 6-month hair transformation using Dutasteride, oral Minoxidil, ketoconazole shampoo, vitamin D, gym, cardio, and dermastamping. He reported significant hair maintenance and no side effects.

community Have to share with you guys. I’m 41. Can’t believe this is actually working. I was bald as hell 1 year ago. I have a ways to go still. Pics of all products included. Most purchased on Amazon

in Progress Pictures 1315 upvotes 7 months ago

A user shared their successful hair regrowth using a combination of derma stamping, Retinol, Minoxidil, Dutasteride, and RU58841, with no side effects. Others discussed their varied experiences with these treatments, including concerns about potential side effects like heart issues and sexual dysfunction.

community 3 months of hair treatment! I think I’m hyper responsive to my treatment. Finasteride, biotin pills, derma roller with rosemary/jojoba oil applied after, coffee in the morning for caffeine . No diet or alcohol consumption changes.

in Progress Pictures 491 upvotes 11 months ago

The user reports significant hair regrowth after three months using finasteride, biotin pills, a derma roller with rosemary/jojoba oil, and drinking coffee, despite an initial increase in hair shedding. Other users share varied results with similar treatments, with some not experiencing improvements.

community Pyrilutamide six months update{ New Progress Pics}

in Progress Pictures 320 upvotes 1 year ago

A user shared a six-month update on hair improvement using Pyrilutamide and Minoxidil, noting significant hair regrowth and strength. Some participants questioned the legitimacy of the results and the source of Pyrilutamide.

community Phase II Clinical Trial for TDM-105795 started recruiting

in Research/Science 23 upvotes 1 year ago

A Phase II clinical trial for TDM-105795 has started recruiting in the US, and it might be a promising treatment for hair loss. Many hair loss drugs, including this one, originate from China.

community [20M] 2 Year Fin&Min Progress (Detailed & Pics)

in Progress Pictures 16 upvotes 1 year ago

A 20 year old male's experience with hair loss treatments, including finasteride, minoxidil, microneedling, nizoral shampoo, dutasteride, alfatradiol, stemoxydine and RU58841, over the course of two years. The user reported losing ground overall but their hair becoming curly, which helped hide more scalp.

community ASC-J9: Poor man’s GT-20029 that might work for regrowth. Anyone try this stuff?

in Research/Science 1 year ago

The potential hair regrowth benefits of ASC-J9, a synthetic modified version of curcumin that is said to be more effective than Minoxidil and Finasteride. Reports from users suggest good thickening and temple regrowth with topical use at 0.025% concentration.

community 2 year progress on fin, min, ru, dermarolling, nizoral. Experienced low libido. AMA

in Progress Pictures 74 upvotes 1 year ago

A user's experience with treating their hair loss using finasteride, minoxidil, RU58841, dermarolling, and nizoral; specifically discussing dosage levels of the medications and effects on libido.

community Kintor has announced the results for their human Phase I trials of GT20029

in Research/Science 257 upvotes 1 year ago

The conversation discusses the potential of a new hair loss treatment, GT20029, which may prevent hair loss by destroying androgen receptors on the scalp. Users express hope for the treatment's success and speculate on its usage routine, effectiveness, and possible side effects.

community Please listen. If you want to save your hair.

in Progress Pictures 126 upvotes 2 years ago

User discusses two medications for stopping hair loss: Fin (finasteride) and Dut (dutasteride). Mixed experiences and side effects are shared, with some users seeing positive results.

community Start taking care of your skin and hair loss TODAY! I was telling myself I didn’t care, but I think the difference in my facial expression says it all. Take action asap before more permanent damage is done. I hope I can inspire some of you, because it’s so worth it. Not for others, for yourself! <3

in Progress Pictures 583 upvotes 2 years ago

User shared progress in treating hair loss and improving skin, using treatments like finasteride, minoxidil, RU58841, tretinoin, microneedling, and skin care regimen. Others commented on the impressive results and asked about costs and side effects.

community Minoxidil and microneedling only - one year progress (m40+)

in Progress Pictures 1340 upvotes 3 months ago

A 40+ male shared his one-year progress using minoxidil twice daily and microneedling once a week, showing significant hair improvement. He also occasionally uses finasteride in a low dosage due to side effects.

community Jordan Peterson got a sick hair transplant!

in Transplants 1079 upvotes 9 months ago

The conversation is about Jordan Peterson allegedly getting a hair transplant, with various users mocking his way of speaking and debating the ethics of him potentially hiding the procedure. Some users discuss the natural look of the transplant and the implications of getting one at an older age.

community Safety of RU-58841: I talked to the Pharma Company that researched it, Human Clinical Trials, and Potential Reasons for Discontinuation

in Research/Science 142 upvotes 1 year ago

The safety and effectiveness of RU-58841 as a hair loss treatment, with some users reporting side effects like chest pains, while others had positive results. The original research on RU-58841 was likely stopped due to financial issues, not safety concerns.

community Is Pyri worth it at the moment?

in Chat 26 upvotes 1 year ago

The conversation is about the effectiveness and safety of a hair loss treatment called Pyri, with users discussing its availability and comparing it to other treatments like RU58841, fluridil, and alfatradiol. Some users are waiting for FDA approval before using Pyri, while others share their positive experiences with RU58841 and suggest additional treatments with minimal side effects.

community Topical Saw Palmetto: An Alternative to Microdosing Topical Finasteride?

in Product 16 upvotes 1 year ago

The user is exploring topical Saw Palmetto as a milder alternative to microdosing topical Finasteride for hair loss, aiming to minimize systemic DHT impact. They plan to experiment with this herbal remedy for a year to assess its effectiveness on their mild androgenetic alopecia without significant side effects.