TLDR The drug was successfully released into hair follicles using nanocarriers.
The study investigated the release of the model drug TRITC-dextran from FITC-labeled BSA hydrogel nanocarriers in the hair follicles of porcine ear skin. The nanocarriers, with a size of 663 ± 48 nm, were applied topically, and their penetration and drug release were analyzed using confocal laser scanning microscopy. The results showed that TRITC-dextran penetrated deeper into the follicular ducts compared to the FITC-labeled particles, indicating successful drug release. The release was triggered by altering the concentration gradient through washing the nanocarriers, demonstrating a potential method for targeted drug delivery in hair follicles.
29 citations
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November 2015 in “Acta Biomaterialia” Infrared light can trigger drug release from gold nanoparticle carriers in hair follicles.
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September 2016 in “Journal of Controlled Release” Nanoparticles can improve drug delivery to hair follicles but struggle to penetrate deeper skin layers.
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November 2024 in “International Journal of Pharmaceutics” Larger positively charged gelatin nanoparticles are more effective for delivering treatments to hair follicles.
