Gradient-Dependent Release of the Model Drug TRITC-Dextran from FITC-Labeled BSA Hydrogel Nanocarriers in the Hair Follicles of Porcine Ear Skin

    October 2016 in “ European Journal of Pharmaceutics and Biopharmaceutics ”
    Ngo Bich Nga Nathalie Tran, Fanny Knorr, Wing Cheung Mak, Kwan Yee Cheung, Heike Richter, Martina C. Meinke, Jürgen Lademann, Alexa Patzelt
    Studysummary In this study, FITC-labeled BSA nanocarriers delivered a model drug deeper into porcine ear skin hair follicles than the carriers themselves, as shown by confocal microscopy. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the release of the model drug TRITC-dextran from FITC-labeled BSA hydrogel nanocarriers in the hair follicles of porcine ear skin. The nanocarriers, with a size of 663 ± 48 nm, were applied topically, and their penetration and drug release were analyzed using confocal laser scanning microscopy. The results showed that TRITC-dextran penetrated deeper into the follicular ducts compared to the FITC-labeled particles, indicating successful drug release. The release was triggered by altering the concentration gradient through washing the nanocarriers, demonstrating a potential method for targeted drug delivery in hair follicles.
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