TLDR The drug was successfully released into hair follicles using nanocarriers.
The study investigated the release of the model drug TRITC-dextran from FITC-labeled BSA hydrogel nanocarriers in the hair follicles of porcine ear skin. The nanocarriers, with a size of 663 ± 48 nm, were applied topically, and their penetration and drug release were analyzed using confocal laser scanning microscopy. The results showed that TRITC-dextran penetrated deeper into the follicular ducts compared to the FITC-labeled particles, indicating successful drug release. The release was triggered by altering the concentration gradient through washing the nanocarriers, demonstrating a potential method for targeted drug delivery in hair follicles.
29 citations
,
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,
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,
February 2011 in “Journal of Controlled Release” Medium-sized particles penetrate hair follicles better than smaller or larger ones, which could improve delivery of skin treatments.
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,
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323 citations
,
April 2006 in “The journal of investigative dermatology/Journal of investigative dermatology” Only 40 nm nanoparticles can enter skin cells effectively for potential vaccine delivery.
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,
November 2005 in “International journal of pharmaceutics” Hair follicles may soon be used more for targeted and systemic drug delivery.
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,
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,
April 2021 in “International Journal of Pharmaceutics” Serum formulations were better at delivering molecules to the hair bulb than nanoparticles.
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January 2015 in “D-Scholarship@Pitt (University of Pittsburgh)” Diabetic patients' stem cells make vascular grafts more prone to clots, but new methods may improve grafts.
42 citations
,
February 2000 in “Journal of Investigative Dermatology” Type VII collagen absence helps skin development by allowing tissue remodeling.
