Advanced Skin Antisepsis: Application of UVA-Cleavable Hydroxyethyl Starch Nanocapsules for Improved Eradication of Hair Follicle-Associated Microorganisms

February 2023 in “ Pharmaceutics ”

Loris Busch, Anna Maria Hanuschik, Yuri Avlasevich, Katrin Darm, Elisa F. Hochheiser, Christian Köhler, Evgeny A. Idelevich, Karsten Becker, Peter Rotsch, Katharina Landfester, Maxim E. Darvin, Martina C. Meinke, Cornelia M. Keck, Axel Krämer, Paula Zwicker

UVA-cleavable hydroxyethyl starch nanocapsules HES-NCs UVA irradiation hair follicle-associated microorganisms microbial load ex vivo porcine skin UVA-LED lamp ethanol preoperative skin antisepsis surgical site infections endogenous pathogens UVA-cleavable HES nanocapsules UVA light microorganisms in hair follicles bacteria skin disinfection surgery infection prevention

Studysummary This study suggests that UVA-responsive nanocapsules may provide an effective method for skin antisepsis by releasing ethanol and reducing microorganisms within hair follicles on ex vivo porcine ear skin.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

18 / 18 results

research Development and Skin Penetration Pathway Evaluation Using Confocal Laser Scanning Microscopy of Microemulsions for Dermal Delivery Enhancement of Finasteride

1 citations , December 2022 in “Pharmaceutics”

This study found that finasteride-loaded microemulsions using poloxamer 124 significantly enhanced skin penetration of the drug compared to a standard solution, primarily through targeting hair follicles via the transfollicular pathway, with intercluster, intercellular, and transcellular pathways contributing less.

research Multi-Modal Imaging to Assess the Follicular Delivery of Zinc Pyrithione

6 citations , May 2022 in “Pharmaceutics”

This study demonstrates that MPM-FLIM multimodal imaging can effectively assess the delivery and dissolution of zinc pyrithione particles in human skin follicles using different application techniques.

research Minoxidil Nanoparticles Targeting Hair Follicles Enhance Hair Growth in C57BL/6 Mice

5 citations , April 2022 in “Pharmaceutics”

This study reported that 5% minoxidil nanoparticles enhanced hair growth more effectively in mice than a commercial minoxidil solution, with significantly higher drug accumulation in the upper hair follicles.

Safflower Oil Body Nanoparticles Deliver hFGF10 to Hair Follicles and Reduce Microinflammation to Accelerate Hair Regeneration in Androgenetic Alopecia

research Safflower Oil Body Nanoparticles Deliver hFGF10 to Hair Follicles and Reduce Microinflammation to Accelerate Hair Regeneration in Androgenetic Alopecia

7 citations , February 2022 in “International Journal of Pharmaceutics”

In a mouse model of androgenetic alopecia, this study found that a safflower oil body nanoparticle loaded with human fibroblast growth factor 10 significantly improved hair regeneration and reduced associated microinflammation without significant toxicity.

research Nanostructured Lipid Carriers Loaded with Minoxidil and Latanoprost for Targeted Topical Therapy of Alopecia

9 citations , February 2022 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study suggests that a nanostructured lipid carrier formulation delivering minoxidil and latanoprost may enhance effectiveness and tolerability in treating alopecia by targeting hair follicles.

research Follicular-Targeted Delivery of Spironolactone Provided by Polymeric Nanoparticles

18 citations , September 2021 in “Colloids and surfaces. B, Biointerfaces”

This study explored the development of polymeric nanoparticles for topical spironolactone delivery, finding that larger nanoparticles (180 nm) enhanced drug targeting to hair follicles significantly more than smaller ones or non-nanoparticle formulations, offering promise for safer acne and alopecia treatments.

research The Impact of Skin Massage Frequency on the Intrafollicular Transport of Silica Nanoparticles: Validation of the Ratchet Effect on an Ex Vivo Porcine Skin Model

21 citations , November 2020 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study found that low massage frequencies like 4.2 Hz enhance nanoparticle penetration into hair follicles more effectively than higher frequencies, indicating potential applications in therapeutic and cosmetic delivery.

research Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases

15 citations , November 2020 in “Pharmaceutics”

In this ex vivo and mouse model study, Tofacitinib-loaded nanoparticles demonstrated enhanced delivery of the drug into hair follicles and reduced inflammatory effects compared to conventional forms, indicating potential for safer, topical use in treating alopecia areata.

research Determination of the pH Gradient in Hair Follicles of Human Volunteers Using pH-Sensitive Melamine Formaldehyde-Pyranine Nile Blue Microparticles

13 citations , September 2020 in “Sensors”

This study used melamine formaldehyde particles to measure a pH gradient along the hair shaft, showing a significant pH decrease from the hair sheath to the external shaft.

Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

research Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

40 citations , January 2018 in “Pharmaceutics”

This study found that nanoemulsions incorporating skin penetration enhancers significantly increased the permeation of minoxidil through human skin compared to aqueous control solutions.

research Gradient-Dependent Release of the Model Drug TRITC-Dextran from FITC-Labeled BSA Hydrogel Nanocarriers in the Hair Follicles of Porcine Ear Skin

18 citations , October 2016 in “European Journal of Pharmaceutics and Biopharmaceutics”

In this study, FITC-labeled BSA nanocarriers delivered a model drug deeper into porcine ear skin hair follicles than the carriers themselves, as shown by confocal microscopy.

research Do Nanoparticles Have a Future in Dermal Drug Delivery?

87 citations , September 2016 in “Journal of Controlled Release”

Nanoparticles can improve drug delivery to hair follicles but struggle to penetrate deeper skin layers.

research Triggered Release of Model Drug from Gold Nanoparticle-Doped Bovine Serum Albumin Nanocarriers in Hair Follicles Using Infrared A Radiation

29 citations , November 2015 in “Acta Biomaterialia”

This study found that water-filtered infrared A radiation can induce the release of a model drug from gold nanoparticle-doped particles in hair follicles in an ex vivo porcine skin model, suggesting feasibility for follicular drug delivery systems.