Formulation and Evaluation of Minoxidil Loaded Submicron Emulsion Based Topical Gel for Treatment of Alopecia

    December 2023 in “ Azerbaijan Pharmaceutical and Pharmacotherapy J ”
    Jasjeet Kaur Narang, Ramandeep Singh Narang, . Mehak
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    TLDR The minoxidil gel could be a better treatment for hair loss than traditional forms.
    The study formulated a minoxidil-loaded submicron emulsion-based topical gel for alopecia treatment. The emulsion was prepared using Clove oil, Tween 20, and Transcutol P, with the optimized formulation (M5) showing a pH of 5.4, in vitro release of 95.08%, ex vivo permeation of 79.36%, and a particle size of 181.3nm. The M5 formulation was then converted into a gel using Carbopol 934. The gel showed anti-oxidant potential and remained stable for three months. The study concluded that this minoxidil-loaded submicron emulsion-based topical gel could be a beneficial nano-approach for treating alopecia compared to traditional topical dosage forms.
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