Formulation and Evaluation of Topical Gel Containing Hair Growth Promoters for the Treatment of Androgenic Alopecia
January 2014
Studysummary In this study, the researchers developed and evaluated a Minoxidil emulgel formulation, finding that it had a higher drug release rate compared to Minoxidil gels.
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The study aimed to develop and evaluate a Minoxidil emulgel for treating androgenic alopecia and compare it with Minoxidil gels. Minoxidil was dissolved in a water and propylene glycol solvent system, combined with liquid paraffin, and mixed with carbopol gel to form the emulgel. Eight formulations were prepared, four gels and four emulgels, and evaluated for physicochemical properties, in vitro drug release, and ex vivo permeation. The emulgel formulation F6 showed a higher cumulative release (72.31%) after 8 hours compared to the gel formulation F1 (56.30%).
