Characterization of Recombinant Human Liver Thermolabile Phenol Sulfotransferase with Minoxidil as the Substrate

    May 1995 in “ Biochemical and Biophysical Research Communications ”
    Patrick E. Kudlacek, Dahn L. Clemens, R. J. Anderson
    TLDR Both enzyme forms can sulfate minoxidil.
    The study investigated the role of thermolabile phenol sulfotransferase in the sulfation of minoxidil, a hair growth stimulator, using a human liver cDNA clone. It was previously thought that only the thermostable form of the enzyme catalyzed this reaction. However, the research confirmed that the thermolabile form also sulfated minoxidil, similar to its activity with dopamine. This finding suggested that both enzyme forms should be considered when assessing the contribution of human tissue sulfotransferase to minoxidil metabolism.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Hair partition and Minoxidil Application

      in Minoxidil  2 upvotes 5 days ago
      A user is experiencing hair loss and is using Morr F 5% Minoxidil, Finasteride Lipid Solution, ketoconazole shampoo, and biotin tablets. They seek advice on the correct application method and hair partitioning.

      community Minoxidil asking advice as an 23F

      in Minoxidil  1 upvotes 1 week ago
      A 23-year-old woman is considering starting minoxidil for hair thinning but is concerned about its long-term use and effectiveness. Recommendations include consulting a doctor, checking ferritin levels, and considering treatments like spironolactone or finasteride, while minoxidil is suggested for regrowth but not as a primary treatment.

      community Using minoxidil for 6 months. Not seeing results

      in Minoxidil  111 upvotes 1 week ago
      Minoxidil alone is not effective for hair regrowth; adding a DHT blocker like finasteride or dutasteride is recommended. Dermastamping and micro-needling can enhance results, and some users suggest trying oral minoxidil or natural DHT blockers.

    Related Research

    3 / 3 results