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Did you mean Lysyl Hydroxylase?

Glossary Lysyl Hydroxylase

enzyme modifying lysine in collagen for tissue strength

Lysyl Hydroxylase is an enzyme that plays a crucial role in the formation of collagen, a protein that provides structure and strength to connective tissues like skin, hair, and bones. It specifically modifies lysine residues in collagen, enabling the collagen fibers to form stable cross-links, which are essential for the tissue's mechanical properties. Deficiencies or mutations in this enzyme can lead to connective tissue disorders.

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Research

5 / 243 results

Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

research Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis

38 citations , June 2005 in “Matrix Biology”

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

research Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note

2 citations , October 2020 in “Journal of Pharmacology and Experimental Therapeutics”

This study found that in a mouse model of bronchopulmonary dysplasia, minoxidil administered at 50 mg/kg/day did not impact lung development or inhibit lysyl hydroxylation.

research Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil.

63 citations , September 1987 in “Journal of Biological Chemistry”

Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.

research Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity

April 2012 in “KSBB Journal”

This study suggests that specific structural features of minoxidil analogs, such as hydrophobic and hydrogen bond field contributions, are key to enhancing lysyl hydroxylase inhibitory activity, which could inform future hair growth treatments.

research Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis

6 citations , August 2024 in “Biomacromolecules”

This study introduces a novel in vitro model for clubfoot fibrosis to enable high-throughput drug screening and found that while the model increased collagen deposition, the antifibrotic drug minoxidil effectively inhibited the expression of collagen cross-linking enzymes.

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Community Join

5 / 9 results

community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

32 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community Replacing Minoxidil with Castor oil. Does it have similar side effects?

4 upvotes 5 years ago

The user experienced side effects from minoxidil, including hirsutism and facial changes, and switched to castor oil, which has not caused similar side effects. They continue using microneedling and dutasteride, reporting minor hair shedding but no significant hair loss.

community Minoxidil actually reduces wrinkles

in Research/Science 209 upvotes 1 year ago

Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

community Copper Literally Saved My Life (and My Baldness)

31 upvotes 1 year ago

Oral copper supplementation significantly improved hair regrowth for someone who experienced severe hair loss after stopping minoxidil, suggesting copper deficiency might hinder minoxidil's effectiveness. The user now only takes copper and occasionally uses microneedling, recommending others to try copper if minoxidil alone isn't effective.

community So does oral minoxidil age your skin or not

43 upvotes 2 years ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

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learn lysine

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