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    Did you mean Lysyl Hydroxylase?
    Glossary Lysyl Hydroxylase

    enzyme modifying lysine in collagen for tissue strength

    Lysyl Hydroxylase is an enzyme that plays a crucial role in the formation of collagen, a protein that provides structure and strength to connective tissues like skin, hair, and bones. It specifically modifies lysine residues in collagen, enabling the collagen fibers to form stable cross-links, which are essential for the tissue's mechanical properties. Deficiencies or mutations in this enzyme can lead to connective tissue disorders.

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    Research 30 of 199

    1. Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis Matrix Biology · 2005 · 38 citations
    2. Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note Journal of Pharmacology and Experimental Therapeutics · 2020 · 2 citations
    3. Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil. Journal of Biological Chemistry · 1987 · 63 citations
    4. Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity KSBB Journal · 2012
    5. Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis Biomacromolecules · 2024 · 6 citations
    6. Acne Scar Management: Minoxidil as a Promising Approach or a Mirage? International journal of biomedicine · 2023
    7. Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action Dermatology · 2009 · 37 citations
    8. Effects of Minoxidil on Cultured Human Skin Fibroblasts Dermatology · 1987 · 19 citations
    9. Inflammatory perifollicular fibrosis and alopecia International Journal of Dermatology · 1998 · 10 citations
    10. Androgenetic alopecia, trichotrophic substances, and histologic studies of the human scalp Clinics in Dermatology · 1988 · 5 citations
    11. The Effect of the Drug Minoxidil on Hair Growth 1988 · 3 citations
    12. Cardiac Outflow tract septation defects in a DiGeorge syndrome model respond to Minoxidil treatment. bioRxiv (Cold Spring Harbor Laboratory) · 2024
    13. Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987 Clinical and Experimental Dermatology · 1989
    14. Chelators Depigment and Inorease Elasticity of Mink Skin Acta Agriculturae Scandinavica · 1987 · 2 citations
    15. Minoxidil Stimulates Elastin Expression in Aortic Smooth Muscle Cells Archives of Biochemistry and Biophysics · 1994 · 33 citations
    16. Stimulation of elastin expression by minoxidil in chick skin fibroblasts Archives of Dermatological Research · 1995 · 15 citations
    17. Cosmeceuticals in Dermatology Springer eBooks · 2013 · 1 citations
    18. From a stem-cell–centered to a niche-centered view: the core role of collagen networks in hair loss and hair follicle miniaturization Frontiers in Cell and Developmental Biology · 2026
    19. Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases Pharmacological Reports · 2023 · 47 citations
    20. Hormone replacement therapy and the skin Maturitas · 2000 · 138 citations
    21. Estrogens and the skin Climacteric · 2005 · 137 citations
    22. Skin connective tissue and ageing Best Practice & Research in Clinical Obstetrics & Gynaecology · 2013 · 77 citations
    23. Oral Manifestations of Hematologic and Nutritional Diseases Otolaryngologic Clinics of North America · 2010 · 50 citations
    24. The effect of menopause on the skin and other connective tissues Gynecological Endocrinology · 2011 · 44 citations
    25. The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches Annual Review of Cell and Developmental Biology · 2016 · 42 citations
    26. Pseudoacromegaly induced by the long-term use of minoxidil Journal of The American Academy of Dermatology · 2003 · 41 citations
    27. Limitations of human occipital scalp hair follicle organ culture for studying the effects of minoxidil as a hair growth enhancer Experimental Dermatology · 2004 · 30 citations
    28. Experimental and thermodynamic analyses of supercritical CO2-Solubility of minoxidil as an antihypertensive drug Fluid Phase Equilibria · 2020 · 28 citations
    29. ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1 Frontiers in Physiology · 2018 · 17 citations
    30. The induction by topical minoxidil of increased fenestration in the perifollicular capillary wall British Journal of Dermatology · 1999 · 12 citations