Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity

    April 2012 in “ KSBB Journal ”
    Pyung-Keun Myung, Nack‐Do Sung, Jae-Heung Lee
    Studysummary This study suggests that specific structural features of minoxidil analogs, such as hydrophobic and hydrogen bond field contributions, are key to enhancing lysyl hydroxylase inhibitory activity, which could inform future hair growth treatments.
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    Research cited in this study 10

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    2. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    3. The Value of Hair Cosmetics and Pharmaceuticals Dermatology · 2001
    4. Minimum Structural Requirements for Minoxidil Inhibition of Lysyl Hydroxylase in Cultured Fibroblasts Archives of Biochemistry and Biophysics · 1994
    5. Potassium Channel Conductance as a Control Mechanism in Hair Follicles Journal of Investigative Dermatology · 1993
    6. Potassium Channel Conductance as a Control Mechanism in Hair Follicles Journal of Investigative Dermatology · 1993
    7. Enzymatic and Non-Enzymatic Sulfation Mechanisms in the Biological Actions of Minoxidil Biochemical Pharmacology · 1993
    8. Minoxidil Specifically Decreases the Expression of Lysine Hydroxylase in Cultured Human Skin Fibroblasts Biochemical Journal · 1992
    9. Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil Journal of Biological Chemistry · 1987
    10. Reversal of Baldness in Patient Receiving Minoxidil for Hypertension The New England Journal of Medicine · 1980