Androgenic Alopecia

January 2003 in “ Springer eBooks ”

Piérard-Franchimont C, Gérald Pierard

androgenic alopecia androgens hair follicles hair cycle miniaturization hormonal imbalance

Studysummary This article discusses the hereditary aspect of androgenic alopecia and its dependence on androgen effects, but reports no new clinical data.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document from 2002 discussed androgenic alopecia, a type of hair loss that is at least partially hereditary and depends on the impact of androgens on hair follicles in specific areas of the scalp. This condition results in a progressive shortening of the hair cycle and miniaturization of the hair follicle. It was noted as a physiological process in men, and in women, it could be secondary to hormonal imbalance.

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Research cited in this study

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research Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia

239 citations , November 2000 in “Journal of The American Academy of Dermatology”

In this study, finasteride 1 mg/day for 12 months did not improve hair growth or slow hair thinning in postmenopausal women with androgenetic alopecia compared to placebo.

research Androgenetic Alopecia and Microinflammation

131 citations , August 2000 in “International Journal of Dermatology”

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Application of 5% and 2% Topical Minoxidil, Placebo, or No Treatment

research Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Application of 5% and 2% Topical Minoxidil, Placebo, or No Treatment

115 citations , November 1999 in “Journal of The American Academy of Dermatology”

In this study, men using 2% and 5% minoxidil solutions experienced a significant increase in hair weight for 96 weeks compared to placebo, with effects diminishing after treatment cessation.

research Treatment of Hair Loss

370 citations , September 1999 in “The New England Journal of Medicine”

This article discusses the treatment of androgenetic alopecia and alopecia areata with finasteride and minoxidil but reports no new clinical results.

research Finasteride in the Treatment of Men with Frontal Male Pattern Hair Loss

187 citations , June 1999 in “Journal of The American Academy of Dermatology”

This study reported that finasteride 1 mg/day significantly increased hair growth and slowed hair loss in men with frontal scalp hair thinning over one year, and these benefits continued or improved in the second year.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations , October 1998 in “Journal of The American Academy of Dermatology”

In male pattern hair loss, this study found that finasteride 1 mg daily significantly slowed hair loss and increased hair growth over two years compared to placebo.

research Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia

92 citations , January 1998 in “Dermatology”

This study found that 2% ketoconazole shampoo improved hair density and anagen follicle proportion in androgenic alopecia similarly to minoxidil treatment, suggesting a potential role for Malassezia in inflammation.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research 5α-Reductase Inhibitors: A New Hope in Dermatology?

15 citations , March 1997 in “International Journal of Dermatology”

This article discusses the potential use of 5α-reductase inhibitors in dermatology and reports no new clinical results; the authors suggest further exploration of their dermatological applications.

research Topical Finasteride in the Treatment of Androgenic Alopecia: Preliminary Evaluations After a 16-Month Therapy Course

30 citations , January 1997 in “Journal of Dermatological Treatment”

This study reported that a 0.005% finasteride solution may encourage hair regrowth and reduce balding areas in patients with androgenic alopecia, without significant absorption or adverse effects.

Treatment of Androgenetic Alopecia with a 7.5% Herbal Preparation