Molybdenum Nanoparticles as a Potential Topical Medication for Alopecia Treatment

March 2024 in “ Journal of Trace Elements in Medicine and Biology ”

Qin Xiao, Yongzhou Lu, Wei Yao, Chengchen Gong, Chuanlong Jia, Guojun Jin, Jing Guo, Tianwen Qiu, Yebin Jiang, Min Huang, Wenhua Chu, Qiannan Xu, Nan Xu

molybdenum nanoparticles alopecia oxidative stress minoxidil SULT sulfate transfer hair growth C57BL/6 mice Mo nanoparticles hair loss Rogaine

TLDR Molybdenum nanoparticles could be a new treatment for hair loss, working differently than minoxidil.

The study "Molybdenum Nanoparticles as a Potential Topical Medication for Alopecia Treatment through Antioxidant Pathways that Differ from Minoxidil" explores the potential of molybdenum (Mo) nanoparticles in treating alopecia. The researchers hypothesized that Mo nanoparticles could promote hair growth by reducing oxidative stress and accelerating minoxidil-treated hair growth by upregulating SULT and sulfate transfer. To test this, they synthesized Mo nanoparticles and applied them to hair-removed mice. The results suggest that Mo nanoparticles could be a potential treatment for alopecia, offering a different mechanism from the FDA-approved treatment, minoxidil, which has a relatively low efficacy of 30-40%. The study was conducted on seven-week-old male C57BL/6 mice, divided into different treatment groups.

View this study on sciencedirect.com →

Discuss this study in the Community →

Cited in this study

15 / 15 results

research The Burden of Alopecia Areata: A Scoping Review Focusing on Quality of Life, Mental Health, and Work Productivity

10 citations , February 2023 in “Journal of the European Academy of Dermatology and Venereology”

Alopecia areata greatly affects people's life quality, mental health, and work life.

research Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches

15 citations , January 2023 in “Antioxidants”

Oxidative stress plays a significant role in alopecia areata, and new treatments may include JAK inhibitors and antioxidants.

research Effects of Taurine and Apocynin on the Zone of Stasis

1 citations , December 2022 in “Burns”

Taurine and apocynin together improve burn healing, especially later in recovery.

research Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature

8 citations , December 2022 in “Regenerative Therapy”

New regenerative treatments for hair loss show promise but need more research for confirmation.

research Exploiting Recent Trends in the Treatment of Androgenic Alopecia Through Topical Nanocarriers of Minoxidil

1 citations , November 2022 in “Aaps Pharmscitech”

research Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia

1 citations , August 2022 in “Journal of Dermatological Treatment”

research Hair Shaft Miniaturization Causes Stem Cell Depletion Through Mechanosensory Signals Mediated by a Piezo1-Calcium-TNF-α Axis

23 citations , January 2022 in “Cell Stem Cell”

Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.

research Extract of Plumbago Zeylanica Enhances the Growth of Hair Follicle Dermal Papilla Cells with Down-Regulation of 5α-Reductase Type II

4 citations , March 2020 in “Journal of Cosmetic Dermatology”

Plumbago zeylanica extract helps hair growth and reduces a hair loss-related enzyme.

research Sulfotransferase SULT1A1 Activity in Hair Follicle: A Prognostic Marker of Response to Minoxidil Treatment in Androgenetic Alopecia

January 2020 in “Postepy Dermatologii I Alergologii”

Sulfotransferase SULT1A1 activity may predict minoxidil treatment success for hair loss.

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

research iNOS Inhibits Hair Regeneration in Obese Diabetic (ob/ob) Mice

3 citations , July 2018 in “Biochemical and Biophysical Research Communications”

iNOS contributes to hair loss in obese diabetic mice and blocking it may encourage hair growth.

research Scalp Condition Impacts Hair Growth And Retention Via Oxidative Stress

40 citations , January 2018 in “International journal of trichology”

Healthy scalp reduces hair loss by managing oxidative stress.

research Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress During Hair Cycling

22 citations , July 2015 in “PloS one”

Foxp1 helps control hair stem cell growth and response to stress during hair growth cycles.

research Cyclooxygenases in the Skin: Pharmacological and Toxicological Implications

165 citations , November 2003 in “Toxicology and applied pharmacology”

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

research Topical Minoxidil Counteracts Stress-Induced Hair Growth Inhibition in Mice

30 citations , October 2003 in “Experimental Dermatology”

Minoxidil helps prevent stress-caused hair loss in mice.

2 / 2 results

research Alopecia Areata: A Multifactorial Autoimmune Condition

148 citations , March 2019 in “Journal of autoimmunity”

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

research Effectivity of Minoxidil as a Treatment for Alopecia Areata

January 2014 in “DOAJ (DOAJ: Directory of Open Access Journals)”