TLDR A special bioink with nanoparticles helps regrow hair by reducing inflammation and promoting hair growth signals.
The study developed a bioink containing calcium molybdate (CM) nanoparticles, dermal papilla cells (DPCs), and macrophages to promote hair regrowth. The CM nanoparticles created an anti-inflammatory microenvironment by polarizing macrophages to the M2 phenotype, which in turn secreted cytokines that facilitated hair follicle regeneration. The bioink activated the mTOR signaling pathway in macrophages, increasing the expression of growth factors HGF and IGF-1, thus accelerating the transition of hair follicles to the anagen phase. The bioprinted scaffolds demonstrated excellent cytocompatibility and significantly improved hair regrowth in vivo, offering a promising strategy for reconstructing complex skin appendages.
12 citations,
August 2022 in “Journal of Controlled Release” A new microneedle patch effectively promotes hair growth by increasing blood vessel formation around hair follicles.
38 citations,
July 2021 in “ACS Nano” Microneedles help treat hair loss by improving hair surroundings and promoting growth.
2 citations,
March 2021 in “Molecular Immunology” Dermal macrophages might help regrow hair.
65 citations,
July 2020 in “Science Advances” Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.
51 citations,
April 2020 in “Cells” Special cell particles from macrophages can help hair grow.
184 citations,
December 2018 in “Nature Communications” Researchers created human hair follicles using a new method that could help treat hair loss.
36 citations,
April 2018 in “Journal of Investigative Dermatology” Macrophages help hair growth after injury through CX3CR1 and TGF-β1.
113 citations,
November 2017 in “Scientific Reports” Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.
133 citations,
September 2013 in “Nature Reviews Molecular Cell Biology” Different types of stem cells and their environments are key to skin repair and maintenance.
499 citations,
September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
February 2025 in “Stem Cell Research & Therapy” Hair follicle regeneration is advancing but still faces challenges in stability and clinical use.
April 2025 in “BioNanoScience” New methods using biomaterials, stem cells, and nanoparticles show promise for improving hair growth and treating hair loss.
November 2020 in “IntechOpen eBooks” Not getting enough minerals can lead to health problems and shorter lifespans.
26 citations,
October 2017 in “Scientific reports” A special microbe helps plants absorb rock phosphate by growing on their root hairs.
January 2015 in “Indian Journal of Medical Biochemistry” Men with early balding should be checked for metabolic syndrome, as there's a link between the two.
