Mesenchymal Stromal Cell-Derived Magnetic Nanovesicles for Enhanced Skin Retention and Hair Follicle Growth

July 2023 in “ Cytotherapy ”

Lei Wang, Shuya Qiao, Rushan Xia, Yiwen Liu, Yifei Hu, Yihao Wu, Jiaju Zhou, Gaofeng Liang, Tian Tian, Lei Cao

mesenchymal stromal cells magnetic nanovesicles hair follicle growth skin retention therapeutic growth factors external magnetic field cellular proliferation β-catenin signaling hair regeneration subcutaneous injection MSCs MNVs hair growth growth factors magnetic field cell proliferation beta-catenin signaling hair regrowth injection

TLDR Magnetic nanovesicles from stem cells can improve hair growth by staying in the skin longer.

The study investigates the use of magnetic nanovesicles (MNVs) derived from mesenchymal stromal cells (MSCs) to promote hair follicle growth. By incorporating iron oxide nanoparticles into MSCs, the MNVs contained more therapeutic growth factors. In a mouse model, subcutaneous injection of these MNVs, combined with an external magnetic field, increased skin retention, enhanced cellular proliferation, and boosted β-catenin signaling in hair follicles. Histological analysis showed accelerated hair follicle growth, indicating that this method could enhance the therapeutic potential of MSC-derived nanovesicles for hair regeneration and other skin conditions.

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