Mesenchymal Stromal Cell-Derived Magnetic Nanovesicles for Enhanced Skin Retention and Hair Follicle Growth
November 2023
in “
Cytotherapy
”
mesenchymal stromal cells magnetic nanovesicles hair follicle growth skin retention therapeutic growth factors external magnetic field cellular proliferation β-catenin signaling hair regeneration subcutaneous injection MSCs MNVs hair growth growth factors magnetic field cell proliferation beta-catenin signaling hair regrowth injection
TLDR Magnetic nanovesicles from stem cells can improve hair growth by staying in the skin longer.
This study explored the use of magnetic nanovesicles (MNVs) derived from mesenchymal stromal cells (MSCs) to improve hair growth by enhancing skin retention. MNVs, which contained more therapeutic growth factors than standard nanovesicles, were manipulated using an external magnetic field to increase their localization and internalization in the skin. In a mouse model of hair regeneration, subcutaneous injection of MNVs followed by magnetic attraction significantly boosted cellular proliferation and β-catenin signaling in hair follicles, leading to accelerated hair follicle growth. This approach shows promise for enhancing the therapeutic potential of MSC-derived nanovesicles in hair regeneration and other skin-related conditions.
