Morphological Studies of Penetration Pathways via Stratum Corneum and Hair Follicles Using Nano-Sized Iron Oxide

    July 2017 in “ Microscopy and Microanalysis ”
    Ki-Ju Choi, Byungkyu Park, Sung-hun Lee, Qing Wang, Seunghun Lee
    TLDR Iron oxide nanoparticles mainly enter the skin through hair follicles and sebocytes, not the dermis.
    The study investigated the penetration pathways of 15 nm iron oxide nanoparticles (INPs) through the skin of C57BL/6 mice, focusing on the stratum corneum and hair follicles. Using transmission electron microscopy (TEM), researchers found that INPs primarily permeated the upper stratum corneum, hair follicles, and sebocytes via the pilosebaceous duct. The amount of INPs increased in sebocytes with longer application times, and INPs were also observed in the upper hair bulb through the inner root sheath and hair cuticle interface. However, INPs did not permeate the dermis outside of hair follicles and sebocytes. The findings provided valuable data for transdermal drug delivery research.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 594 results

      community Why don’t more people use hair fibers?

      in Product  527 upvotes 2 months ago
      Hair fibers can effectively cover thinning hair when used with minoxidil and hairspray but require daily application and can be inconvenient in certain conditions. Some users prefer treatments like finasteride, dutasteride, microneedling, or wigs due to the maintenance and limitations of hair fibers.

      community The Theory of BURN THE SCALP. !! NEW UPDATES¡¡¡

      in Update  124 upvotes 11 months ago
      The conversation discusses a user's experiment with using hot water and a dermastamp to reduce hair loss, improve dandruff, and promote new hair growth. The user advises caution and mentions not sharing photos until more progress is visible.

      community 8 months apart on the mother of all stacks

      in Progress Pictures  151 upvotes 2 years ago
      User Tricky9555 tried various hair loss treatments for 8 months with no visible results. Others suggested considering a hair transplant, checking thyroid levels, and being patient for up to 24 months for potential results.

    Similar Research

    5 / 1000+ results