Treatment of Hirsutism with a Gonadotropin-Releasing Hormone Agonist and Estrogen Replacement Therapy

    March 1994 in “ Fertility and sterility ”
    Roy N. Morcos, Michael E. Abdul-Malak, Evan Shikora
    TLDR The combination therapy reduced hirsutism in women with PCOD and was well-tolerated.
    The study aimed to evaluate the effectiveness of treating significant hirsutism in women with polycystic ovarian disease (PCOD) using a combination of a gonadotropin-releasing hormone agonist (GnRH-a) and estrogen and progestin replacement therapy. Conducted in an ambulatory gynecology clinic, the study involved 10 women who were treated with leuprolide acetate, estradiol, and medroxyprogesterone acetate for 6 months. Results showed a significant reduction in hirsutism scores and hair growth rates by 23% and 26%, respectively. The duration of hirsutism was the only significant covariate affecting these outcomes. The treatment was well-tolerated, with only two patients experiencing minimal, irregular bleeding, which was managed by adjusting the estrogen dose. The study concluded that this combination therapy was effective and well-tolerated for treating hirsutism in women with PCOD.
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