A Comparative Study of a Gonadotropin-Releasing Hormone Agonist and Finasteride on Idiopathic Hirsutism

January 2000 in “ PubMed ”

Gökhan Bayhan, M. Bahçeci, Taner Demirkol, Metin Ertem, Ahmet Yalinkaya, Erden Ac

gonadotropin-releasing hormone agonist finasteride idiopathic hirsutism GnRH agonist depot leuprolide testosterone free testosterone androstenedion DHEA-S Propecia Lupron

TLDR Both finasteride and GnRH agonist treatments reduced hair growth in women with idiopathic hirsutism, but GnRH agonist was more effective.

In a study conducted 23 years ago, 60 women with idiopathic hirsutism were treated with either 5 mg of finasteride or a long-acting GnRH agonist (depot leuprolide 3.75 mg) monthly for six months. The results showed that all patients treated with either finasteride or GnRH agonist experienced no menstrual abnormalities or side-effects. The mean percent change in hirsutism scores in the GnRH and finasteride groups was 36% +/- 14% and 14% +/- 11% at six months, respectively. Serum total testosterone, free testosterone, androstenedion and DHEA-S showed a significant decrease in patients treated with GnRH agonist. However, only serum total testosterone and free testosterone levels decreased with finasteride treatment.

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A Comparative Study of a Gonadotropin-Releasing Hormone Agonist and Finasteride on Idiopathic Hirsutism