Effects of Intramuscular Testosterone Undecanoate on Body Composition and Bone Mineral Density in Female-to-Male Transsexuals
June 2010
in “
The journal of sexual medicine
”
testosterone undecanoate lean mass BMI fat mass bone mineral density gonadotropins estradiol high-density lipoprotein testosterone triglycerides menstrual bleeding clitoral growth libido body hair growth beard hair growth deepened voices breast size hemoglobin hematocrit liver enzymes systolic blood pressure lipid profiles blood pressure erythrocytosis HDL body hair beard hair
TLDR Testosterone undecanoate increases lean mass and causes various physical changes in female-to-male transsexuals.
The study evaluated the effects of long-acting intramuscular testosterone undecanoate on body composition and bone mineral density in 45 female-to-male transsexuals over 24 months. Results showed a significant increase in lean mass, but no change in BMI, fat mass, or bone mineral density. Hormone levels shifted, with declines in gonadotropins, estradiol, and high-density lipoprotein, and increases in testosterone and triglycerides. Clinical effects included cessation of menstrual bleeding, increased clitoral growth, libido, body and beard hair growth, deepened voices, and reduced breast size. Adverse effects included increased hemoglobin, hematocrit, liver enzymes, and systolic blood pressure. Monitoring for lipid profiles, blood pressure, and erythrocytosis was recommended during therapy.
