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research The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice

73 citations , May 2009 in “Proceedings of the National Academy of Sciences”

This study found that disrupting the Sox21 gene in mice led to progressive hair loss and regrowth, identifying Sox21 as a key regulator of hair shaft cuticle differentiation.

research Characterization of the Human Hair Shaft Cuticle–Specific Keratin-Associated Protein 10 Family

11 citations , May 2013 in “Journal of Investigative Dermatology”

KRTAP10 proteins help form the hair shaft's tough outer layer by interacting with specific hair keratins.

research Human hair shaft proteomic profiling: individual differences, site specificity and cuticle analysis

68 citations , August 2014 in “PeerJ”

This study found that proteomic analysis can distinguish hair samples across different ethnicities and body regions based on keratin protein levels, which may aid forensic hair identification.

Peer Review of Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, and Cuticle Analysis

research Peer Review #2 of "Human hair shaft proteomic profiling: individual differences, site specificity and cuticle analysis (v0.1)"

August 2014

This study found considerable variation in hair shaft proteomic profiles among Caucasian, African-American, Kenyan, and Korean subjects, with individual and site-specific differences observed.

research Peer Review #1 of "Human hair shaft proteomic profiling: individual differences, site specificity and cuticle analysis (v0.1)"

August 2014

This study used proteomic profiling to reveal significant individual and site-specific differences in human hair shaft proteins, which may improve the differentiation of hair based on ethnic origin and individual identity.

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Community Join

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community Hair Shaft Diameter and Density Comparison

13 upvotes 4 weeks ago

The conversation discusses differences in hair shaft diameter and density between thinning and denser areas on the scalp. Treatments mentioned include Minoxidil, finasteride, and dutasteride.

community FDA Policy Shift Explained: What It Actually Means for PP405, VDPHL-01, Breezula and Hair Loss Drug Timelines

in Research/Science 42 upvotes 6 months ago

The FDA policy change may speed up approval for hair loss drugs like PP405, VDPHL-01, and Breezula by potentially eliminating the need for a second confirmatory Phase 3 trial. Approval timelines could be as early as 2028 for some treatments if Phase 3 results are strong.

community Recent trials investigating mesenchymal stem cell derived exosomes demonstrate significant increases in anagen duration and hair shaft caliber by upregulating Wnt/beta-catenin pathways.

4 upvotes 4 weeks ago

Exosomes from mesenchymal stem cells can increase hair growth by enhancing anagen duration and hair shaft thickness through the Wnt/beta-catenin pathway. Phase 2 trials show improved hair counts over 24 weeks.

community Microneedling must reach the stem cells in the upper hair shaft

82 upvotes 4 years ago

Microneedling should target depths of 0.5mm to 1.5mm for hair loss, with weekly sessions at 1mm recommended. Combining microneedling with Minoxidil is common for improved results.

community After using finasteride, did you notice an improvement in the hair shaft in terms of looking more “alive” and shiny?

2 upvotes 7 months ago

Finasteride users reported improvements in hair appearance, including increased thickness, shine, and darker color. Some users noticed their hair looked healthier and less sunburned after starting the treatment.

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Learn

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learn Cetirizine

How does cetirizine reduce inflammation linked to hair loss? Cetirizine is proposed to lower prostaglandin D2 and raise prostaglandin E2 around hair follicles; three small trials of a compounded 1% topical report modest increases in hair density and shaft thickness, with minoxidil doing better head-to-head. Topical cetirizine is off-label and unapproved for hair loss, and the evidence is too thin to call it effective or safe.

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Adenosine

nucleoside used for hair regrowth stimulant properties

learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn Stemoxydine

chemical from L'Oreal that encourages hair to enter growth phase

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas