Evidence for Genetic Heterogeneity in Monilethrix
December 1996
in “
Journal of Investigative Dermatology
”
Research cited in this study
6 / 6 resultsresearch Linkage of Monilethrix to the Trichocyte and Epithelial Keratin Gene Cluster on 12q11-q13
research A Gene for Monilethrix Is Closely Linked to the Type II Keratin Gene Cluster at 12q13
This study mapped monilethrix, a hereditary hair and nail disorder, to the type II keratin cluster on chromosome 12q, marking the first primary human hair disorder localization and implicating defects in "hard" keratins.
research Sequence and Expression of Human Hair Keratin Genes
This study identified and characterized human hair-specific keratin genes, revealing their sequence homology with mouse counterparts and expression in hair follicle precortical cells.
research Regulation of Keratin Gene Expression in Hair Follicle Differentiation
This study found that conserved DNA motifs and expression patterns in keratin genes suggest functional regulatory similarities in hair follicle differentiation across different mammalian species.
research An Ultrahigh-Sulphur Keratin Gene of the Human Hair Cuticle Is Located at 11q13 and Cross-Hybridizes with Sequences at 11p15
research Monilethrix: An Ultrastructural Study
This study observed that the thinning and structural abnormalities in monilethrix-affected hair occur at the internodes due to possible periodic dysfunction of the hair matrix, particularly in the cortex.