Controversial Concepts in the Classification of Infundibular Squamous Cell Carcinoma and Tricholemmal Carcinoma
May 2013
in “
The American Journal of Dermatopathology
”
Studysummary This article discusses the classification and characteristics of infundibular squamous cell carcinoma and highlights the ongoing debate about its differentiation from other carcinoma types, reporting no new clinical results.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The document from June 1, 2013, addresses the controversy surrounding the classification of infundibular squamous cell carcinoma (SCC) and tricholemmal carcinoma, focusing on whether they are distinct entities with follicular differentiation. The author revisits their stance on the nature of the infundibulum, considering it to have both epidermal and follicular characteristics based on recent skin stem cell studies. While initially skeptical, the author now recognizes tricholemmal carcinoma as a rare but related form of infundibular SCC. The differentiation of infundibular SCC from keratoacanthoma is highlighted as clinically significant. The author concurs with calls for further research into the genetic and molecular mechanisms of these tumors.
