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    Glossary Follicular Differentiation

    process where hair follicle cells become specialized for hair growth

    Follicular differentiation is the process by which cells in the hair follicle develop into specialized types that contribute to hair growth. This involves the transformation of stem cells into various cell types, such as those forming the hair shaft, inner root sheath, and sebaceous glands, each playing a crucial role in the structure and function of the hair.

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    1. An immunohistochemical study of the apocrine type of cutaneous mixed tumors with special reference to their follicular and sebaceous differentiation Journal of Cutaneous Pathology · 1999 · 54 citations
    2. The changes in the expression levels of follicular markers in keratoacanthoma depend on the stage: keratoacanthoma is a follicular neoplasm exhibiting infundibular/isthmic differentiation without expression of CK15 Journal of Cutaneous Pathology · 2014 · 28 citations
    3. Immunohistochemical Study of Calretinin in Normal Hair Follicles and Tumors With Follicular Differentiation Actas Dermo-Sifiliográficas · 2008 · 15 citations
    4. Histopathologic Criteria for Follicular Differentiation 2017 · 1 citations
    5. Hair growth induction by the tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras‐dependent up‐regulation of KGF expression The FASEB Journal · 2003 · 51 citations
    6. Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. PubMed · 1995 · 219 citations
    7. Elastic Staining in Differentiating Between Follicular Streamers and Follicular Scars in Horizontal Scalp Biopsy Sections American Journal of Dermatopathology · 2017 · 11 citations
    8. Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels Nature Communications · 2019 · 40 citations
    9. Cytokeratins as Markers of Follicular Differentiation American Journal of Dermatopathology · 2001 · 121 citations
    10. Proliferation and differentiation of cultured human follicular keratinocytes are not influenced by biotin Archives of Dermatological Research · 1995 · 4 citations
    11. Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes 2021 · 11 citations
    12. Trichodysplasia spinulosa: A benign adnexal proliferation with follicular differentiation associated with polyomavirus Australasian journal of dermatology · 2013 · 8 citations
    13. Black Hair Follicular Dysplasia in Black and White Saluki Dogs: Differentiation from Color Mutant Alopecia in the Doberman Pinscher by Microscopic Examination of Hairs Veterinary Dermatology · 1991 · 28 citations
    14. Pitx2, a β-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro Journal of dermatological science · 2009 · 51 citations
    15. Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor 2002 · 169 citations
    16. Ichthyosis, Follicular Atrophoderma, and Hypotrichosis Caused by Mutations in ST14 Is Associated with Impaired Profilaggrin Processing Journal of Investigative Dermatology · 2008 · 99 citations
    17. Keratinocyte differentiation in psoriatic scalp: morphology and expression of epithelial keratins British Journal of Dermatology · 2006 · 63 citations
    18. Follicular ichthyosis 1984 · 17 citations
    19. 889 Trpv3 gain-of-function mutation impairs differentiation of hair follicle inner root sheath 2019
    20. Trichoscopic Differentiation in Alopecia: Retrospective Case Series Comparing Lichen Planopilaris, Discoid Lupus Erythematosus, and Alopecia Areata JMIR Dermatology · 2025
    21. The upper dermal sheath has a potential to regenerate the hair in the rat follicular epidermis Differentiation · 1996 · 31 citations
    22. Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes American Journal of Physiology-cell Physiology · 2003 · 57 citations
    23. Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets. PubMed · 2016 · 39 citations
    24. Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V Frontiers in Genetics · 2021 · 6 citations
    25. Modulating metal-organic frameworks by surface engineering of stearic acid modification for follicular drug delivery and enhanced hair growth promotion Journal of Nanobiotechnology · 2025 · 2 citations
    26. Defining microRNA signatures of hair follicular stem and progenitor cells in healthy and androgenic alopecia patients Journal of Dermatological Science · 2020 · 12 citations
    27. Synergistic treatment of androgenetic alopecia with follicular co-delivery of minoxidil and cedrol in metal-organic frameworks stabilized by covalently cross-linked cyclodextrins International Journal of Pharmaceutics · 2024
    28. Is Trichoscopy A Reliable Method For Differantiation Of Frontal Non-Scarring Alopecias? Research Square · 2026
    29. Perifollicular fibrosis and inflammation in androgenetic alopecia and seborrheic dermatitis: diagnostic challenges in differentiation from fibrosing alopecia in a pattern distribution Anais Brasileiros de Dermatologia · 2026
    30. Faculty Opinions recommendation of The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2008