Histopathologic Criteria for Follicular Differentiation

January 2017

Luís Requena, Omar P. Sangüeza

TLDR The document outlines criteria to identify and differentiate neoplasms based on follicular characteristics.

The document described various histopathologic criteria for identifying follicular differentiation in neoplasms. It detailed specific characteristics for different types of differentiation, such as infundibular, tricholemmal, outer root sheath, matrical, follicular bulb and papilla, inner root sheath, and hair shaft differentiation. Each type was characterized by distinct cellular arrangements, keratinization patterns, and structural features, such as cysts lined by squamous epithelium, neoplastic aggregates with palisade formations, clear epithelial cells, monomorphous epithelial cells with prominent nucleoli, collections of follicular germinative cells, trichohyalin granules, and collections of shadow cells or hairy shafts. These criteria were used to identify and differentiate neoplasms based on their follicular characteristics.

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