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    Glossary Hair Shaft Differentiation

    process where hair follicle cells form distinct hair layers

    Hair Shaft Differentiation refers to the process by which cells in the hair follicle transform into the distinct layers that make up the hair shaft. This involves the specialization of cells into the medulla, cortex, and cuticle, each contributing to the hair's structure, strength, and appearance. This process is crucial for the proper formation and function of hair.

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    1. `Cyclic alopecia' in<i>Msx2</i>mutants: defects in hair cycling and hair shaft differentiation Development · 2002 · 158 citations
    2. EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner iScience · 2019 · 13 citations
    3. Secretory phospholipase A2-IIA overexpressing mice exhibit cyclic alopecia mediated through aberrant hair shaft differentiation and impaired wound healing response Scientific Reports · 2017 · 7 citations
    4. Generation of iPS-derived model cells for analyses of hair shaft differentiation 2017 · 2 citations
    5. Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature 2020 · 15 citations
    6. Supplementary Material for: Case report - Hair shaft normalization and hair growth in SPINK5-syndromic epidermal differentiation disorder (Netherton syndrome) while on treatment with dupilumab: a novel therapeutic approach for Trichorrhexis invaginata Figshare · 2026
    7. Supplementary Material for: Case report - Hair shaft normalization and hair growth in SPINK5-syndromic epidermal differentiation disorder (Netherton syndrome) while on treatment with dupilumab: a novel therapeutic approach for Trichorrhexis invaginata Figshare · 2026
    8. Case report - Hair shaft normalization and hair growth in SPINK5-syndromic epidermal differentiation disorder (Netherton syndrome) while on treatment with dupilumab: a novel therapeutic approach for Trichorrhexis invaginata Case Reports in Dermatology · 2026
    9. Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation Differentiation · 2009 · 35 citations
    10. The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice Proceedings of the National Academy of Sciences · 2009 · 73 citations
    11. 764 DNA dioxygenases Tet1/2/3 control hair matrix keratinocyte differentiation and hair shaft shape via regulation of hair keratin gene expression 2020
    12. Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation Developmental Biology · 2008 · 67 citations
    13. Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers Development · 2000 · 109 citations
    14. Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle The EMBO Journal · 2000 · 305 citations
    15. Dlx3 is a crucial regulator of hair follicle differentiation and cycling Development · 2008 · 132 citations
    16. The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation 2010 · 68 citations
    17. Gsdma3 is required for hair follicle differentiation in mice Biochemical and biophysical research communications · 2010 · 30 citations
    18. Evidence That the Satin Hair Mutant Gene Foxq1 Is among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 during Hair Follicle Differentiation 2006 · 65 citations
    19. Autophagy Controls the Protein Composition of Hair Shafts 2023 · 2 citations
    20. A function for Rac1 in the terminal differentiation and pigmentation of hair Development · 2012
    21. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002 · 146 citations
    22. Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix European Journal of Cell Biology · 2017 · 30 citations
    23. Microscopic sex-based differentiation of human scalp hair among university students in Nigeria Science World Journal · 2025
    24. Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes 2021 · 11 citations
    25. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation Development · 1999 · 990 citations
    26. Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix International Journal of Molecular Medicine · 2014 · 12 citations
    27. Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats PLoS ONE · 2016 · 127 citations
    28. Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity Developmental Biology · 2008 · 28 citations
    29. Transglutaminase 5 Expression in Human Hair Follicle Journal of Investigative Dermatology · 2005 · 28 citations
    30. Localization of Cathepsins B, D, L, LAMP-1 and .MU.-Calpain in Developing Hair Follicles. ACTA HISTOCHEMICA ET CYTOCHEMICA · 2001 · 10 citations