Generation of iPS-Derived Model Cells for the Analysis of Hair Development

    Takumi Kido, Yohei Hirai
    TLDR Researchers created a cell model to study hair growth and test hair-growth drugs.
    Researchers developed a model using induced pluripotent stem (iPS) cells to study hair follicle development. They used a tetracycline-inducible system to introduce BMP-4 cDNA into mouse iPS cells, creating tet-BMP4-iPS cells. When these cells were co-cultured with embryonic skin fibroblasts and treated with retinoic acid (RA) and doxycycline (Dox), they differentiated into hair follicle components, expressing specific keratins at different stages. A luciferase reporter system was also developed to trace hair shaft differentiation, revealing that keratinocyte growth factor (KGF) accelerates this process. This model could be useful for developing and evaluating hair-growth treatments.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 413 results

      community Please explain this Minoxidil phenomena

      in Minoxidil  60 upvotes 1 year ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  138 upvotes 9 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community 22 yr asian male 2 year fin results

      in Progress Pictures  135 upvotes 1 year ago
      The user "Top_Replacement_7777" shared their positive results with finasteride for hair loss. They asked about maintaining their hair with finasteride and the impact of vaping on hair growth. Another user reassured them that vaping wouldn't affect their progress.

    Similar Research

    5 / 1000+ results