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Secretory Phospholipase A2-IIA Overexpressing Mice Exhibit Cyclic Alopecia Mediated Through Aberrant Hair Shaft Differentiation and Impaired Wound Healing Response

research Secretory Phospholipase A2-IIA Overexpressing Mice Exhibit Cyclic Alopecia Mediated Through Aberrant Hair Shaft Differentiation and Impaired Wound Healing Response

7 citations, September 2017 in “Scientific Reports”

Mice with too much sPLA₂-IIA have hair loss and poor wound healing due to abnormal hair growth and stem cell depletion.

research sPLA2-IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation

9 citations, June 2016 in “Stem cells”

Overexpression of sPLA2-IIA in mouse skin reduces hair stem cells and increases cell differentiation through JNK/c-Jun pathway activation.

research Context-Dependent Effect of sPLA2-IIA Induced Proliferation on Murine Hair Follicle Stem Cells and Human Epithelial Cancer

13 citations, September 2019 in “EBioMedicine”

sPLA2-IIA increases growth in hair follicle stem cells and cancer cells, suggesting it could be targeted for hair growth and cancer treatment.

research Group IID, IIE, IIF, and III Secreted Phospholipase A2s

23 citations, August 2018 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

research Are Hair Follicle Stem Cells Promising Candidates for Wound Healing?

18 citations, December 2018 in “Expert Opinion on Biological Therapy”

Hair follicle stem cells are promising for wound healing but require more research for safe clinical use.

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community Research about RU58841 /Why it was stopped

in Research/Science 29 upvotes 3 years ago

RU58841 showed promise for treating androgenic alopecia but research was halted due to financial and organizational changes. There were no significant safety concerns reported in human trials.

community I don’t even care about my hair I just like taking drugs

in Satire 1 year ago

A user's experimentation with various hair loss treatments, including medications and topical applications; as well as their desire to experience unusual sensations through the use of drugs.

community ~5 months topical minoxidil + oral finasteride results (swipe images). Slacked with minoxidil this past month, trying to wean off anyways. My last update because I’m hopping off fin and switching to RU in a few weeks (nothing to do with fin efficacy, just experimenting).

in Progress Pictures 145 upvotes 4 years ago

The user experienced significant hair thickening after using topical minoxidil and oral finasteride for about 5 months and is considering switching from finasteride to RU58841. Other users encourage the original poster to continue the current treatment due to the positive results.

community My Dad seems to get his hair back?

in Question 17 upvotes 5 years ago

A user's father, mostly bald for 20 years, is regrowing hair using a serum called "Skrzypovita Serum Pro" without minoxidil. The user is curious about which ingredients might be causing hair growth.

community My kid secretly took my avodart what should i do

in Is this regrowth? 42 upvotes 2 months ago

A child accidentally took Avodart, leading to concerns about DHT suppression and its effects. Users humorously discuss potential consequences and treatments like DHT injections and topical solutions.

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