Integrated Lipidomics in the Secreted Phospholipase A2 Biology

    February 2011 in “ International Journal of Molecular Sciences ”
    Makoto Murakami, Hiroyasu Sato, Yoshitaka Taketomi, Kei Yamamoto
    TLDR Different sPLA2 enzymes have unique roles in phospholipid metabolism and biological processes.
    The study of secreted phospholipase A2 (sPLA2) enzymes, which are part of a larger family of over 30 phospholipase A2s, revealed their distinct roles in biological processes due to their unique tissue localizations and enzymatic properties. By using transgenic and knockout mice models alongside lipidomics, researchers identified specific contributions of different sPLA2 isoforms to phospholipid metabolism. This integrated approach significantly enhanced the understanding of sPLA2 biology and its pathophysiological implications.
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