Integrated Lipidomics in the Secreted Phospholipase A2 Biology

February 2011 in “ International Journal of Molecular Sciences ”

Makoto Murakami, Hiroyasu Sato, Yoshitaka Taketomi, Kei Yamamoto

secreted phospholipase A2 sPLA2 sPLA2-X alopecia hair follicle structure hair loss

TLDR Different sPLA2 enzymes have unique roles in phospholipid metabolism and biological processes.

The study investigated the roles of secreted phospholipase A2 (sPLA2) enzymes in various biological processes using transgenic and knockout mouse models. It found that sPLA2-V was critical in lung surfactant hydrolysis, leading to respiratory failure, while sPLA2-X was linked to temporary alopecia due to its effect on hair follicle structure. sPLA2-III was associated with systemic inflammation, atherosclerosis, and sperm maturation issues. The research highlighted the potential of sPLA2 enzymes as therapeutic targets for diseases like asthma, ARDS, and atherosclerosis, although a complete understanding of all sPLA2 isoforms remained challenging.

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community DIY treatment... Shedding completely stopped after 1.5 yrs

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